TIMD4 Protein (AA 25-315) (Fc Tag)
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- 抗原 See all TIMD4 蛋白
- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
- 蛋白类型
- Recombinant
- 产品特性
- AA 25-315
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This TIMD4 protein is labelled with Fc Tag.
- 原理
- Tim-4 (human):Fc (mouse) (rec.)
- 特异性
- The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of mouse IgG2a.
- 产品特性
- Protein. The extracellular domain of human Tim-4 (aa 25-315) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell, immunoglobulin, Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <5EU/mg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
- Top Product
- Discover our top product TIMD4 蛋白
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T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-314) protein (His tag)
TIMD4 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-305) protein (His tag)TIMD4 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) protein (His tag)TIMD4 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 94 % as determined by SDS-PAGE
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-314) protein (His tag)Crystallography grade TIMD4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 23-279) protein (His tag)Crystallography grade TIMD4 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 25-378) protein (rho-1D4 tag)Crystallography grade TIMD4 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4) (AA 23-343) protein (rho-1D4 tag)Crystallography grade TIMD4 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- TIMD4 (T-Cell Immunoglobulin and Mucin Domain Containing 4 (TIMD4))
- 别名
- Tim-4 (TIMD4 产品)
- 别名
- RGD1564516 Protein, MGC99322 Protein, TIMD4 Protein, B430010N18Rik Protein, TIM-4 Protein, Tim4 Protein, SMUCKLER Protein, TIM4 Protein, T-cell immunoglobulin and mucin domain containing 4 Protein, T-cell immunoglobulin and mucin domain containing 4 L homeolog Protein, T cell immunoglobulin and mucin domain containing 4 Protein, Timd4 Protein, TIMD4 Protein, timd4.L Protein
- 背景
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Alternate Names/Synonyms: TIM4, TIMD4, T Cell Immunoglobulin and Mucin Domain-containing Protein 4, T Cell Membrane Protein 4
Product Description: The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-4 (T cell, immunoglobulin, Mucin-4), also known as SMUCKLER, is a 60 kDa member of the TIM family of immune regulating proteins. TIM-4 is exclusively expressed on antigen-presenting cells, where it mediates phagocytosis of apoptotic cells and plays an important role in maintaining tolerance. TIM-4 binds specifically to TIM-1 which is also the cellular receptor for the hepatitis A virus, and has been implicated in the development of asthma. Among hematopoietic cells, TIM-1 is expressed on activated B and T cells, preferentially in the Th2 subset of CD4+ T cells. The interaction of TIM-4 with TIM-1 induces costimulatory and hyperproliferative signals in T cells.
- 分子量
- ~80kDa (SDS-PAGE)
- NCBI登录号
- NP_612388
- 途径
- Cancer Immune Checkpoints
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