IL-10RA Protein (AA 22-235) (Fc Tag)
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- 抗原 See all IL-10RA (IL10RA) 蛋白
- IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
- 蛋白类型
- Recombinant
- 产品特性
- AA 22-235
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IL-10RA protein is labelled with Fc Tag.
- 原理
- IL-10Ralpha (human):Fc (human) (rec.)
- 特异性
- The extracellular domain of human IL-10Ralpha (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1.
- 产品特性
- Protein. The extracellular domain of human IL-10Ralpha (aa 22-235) is fused to the N-terminus of the Fc region of human IgG1. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
- 纯度
- >98 % (SDS-PAGE)
- 内毒素水平
- <5EU/mg protein (LAL test, Lonza).
- Biological Activity Comment
- Measured by its ability to inhibit IL-10-dependent proliferation of MC/9- 2 mouse mast cells.
- Top Product
- Discover our top product IL10RA 蛋白
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Interleukin 10 Receptor, alpha (IL10RA) (AA 22-235) protein (His-Avi Tag)
IL10RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 10 Receptor, alpha (IL10RA) (AA 22-233) protein (His tag)IL10RA 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 浓度
- Lot specific
- 缓冲液
- Lyophilized from 0.2μm-filtered solution in PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- 抗原
- IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))
- 别名
- IL-10Ralpha (IL10RA 产品)
- 别名
- IL10R1 Protein, IL10RA Protein, CD210 Protein, CD210a Protein, CDW210A Protein, HIL-10R Protein, IL-10R1 Protein, IL10R Protein, AW553859 Protein, CDw210 Protein, CDw210a Protein, Il10r Protein, mIL-10R Protein, interleukin 10 receptor subunit alpha Protein, interleukin 10 receptor, alpha Protein, IL10RA Protein, Il10ra Protein
- 背景
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Alternate Names/Synonyms: Interleukin-10 Receptor alpha, IL-10RA, CD210, IL-10R1, CDw210a,
Product Description: CD210, also known as IL10RA, is a subunit for the interleukin-10 receptor. IL10RA has also been designated CDW210A (cluster of differentiation W210A). It is structurally related to interferon receptors. CD210 has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It has been reported that CD210 promotes survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of CD210 leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
- 分子量
- ~70kDa (SDS-PAGE)
- 途径
- Growth Factor Binding
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