IL-10RA 产品
(Interleukin 10 Receptor, alpha (IL10RA))
Categories
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009].
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Featured IL-10RA Categories
IL-10RA 抗体
High quality antibodies with extensive validation data.
IL-10RA ELISA试剂盒
Reliable ELISA kits for a wide range of species.
IL-10RA 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IL-10RA 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7433870
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN3022615
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (4)
Cat. No.
ABIN7259833
Quantity
200 μL
Datasheet
Datasheet
Recommended IL-10RA ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956986
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956987
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956988
Quantity
96 tests
Datasheet
Datasheet
Recommended IL-10RA 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (5)
Cat. No.
ABIN7274906
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7274878
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3081876
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our IL-10RA Products
: "Functional analysis of bovine interleukin-10 receptor alpha in response to Mycobacterium avium subsp. paratuberculosis lysate using CRISPR/Cas9." in: BMC genetics, Vol. 21, Issue 1, pp. 121, (2020) (PubMed).: "MYD88 L265P mutation promoted malignant B cell resistance against T cell-mediated cytotoxicity via upregulating the IL-10/STAT3 cascade." in: International immunopharmacology, Vol. 64, pp. 394-400, (2019) (PubMed).
: "Enhanced gut barrier integrity sensitizes colon cancer to immune therapy." in: Oncoimmunology, Vol. 7, Issue 11, pp. e1498438, (2018) (PubMed).
: "Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma." in: The Journal of biological chemistry, Vol. 291, Issue 32, pp. 16686-98, (2016) (PubMed).
: "cmvIL-10 stimulates the invasive potential of MDA-MB-231 breast cancer cells." in: PLoS ONE, Vol. 9, Issue 2, pp. e88708, (2014) (PubMed).
: "Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase." in: PLoS ONE, Vol. 6, Issue 11, pp. e27464, (2011) (PubMed).
: "Role for IL-10 in suppression mediated by peptide-induced regulatory T cells in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 3, pp. 1240-8, (2003) (PubMed).
: "Regulatory activity of autocrine IL-10 on dendritic cell functions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 7, pp. 4312-8, (2001) (PubMed).
: "Cutting edge: interactions through the IL-10 receptor regulate autoimmune diabetes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6087-91, (2001) (PubMed).
: "IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways." in: The EMBO journal, Vol. 17, Issue 4, pp. 1006-18, (1998) (PubMed).
Synonyms and alternative names related to IL-10RA
interleukin 10 receptor subunit alpha (IL10RA), interleukin 10 receptor, alpha (Il10ra), interleukin 10 receptor subunit alpha (Il10ra), AW553859, CD210, CD210a, CDw210, CDW210A, CDw210a, HIL-10R, IL-10R1, IL10R, Il10r, IL10R1, IL10RA, mIL-10RProtein level used designations for IL-10RA
- interleukin 10 receptor 1
- interleukin-10 receptor subunit alpha
- interleukin 10 receptor, alpha
- interleukin-10 receptor subunit alpha-like
- IL-10 receptor subunit alpha
- IL-10R subunit 1
- IL-10R subunit alpha
- IL-10RA
- interleukin-10 receptor alpha chain
- interleukin-10 receptor subunit 1
- IL-10R1
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