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IHOG 抗体

IHOG 适用: Drosophila melanogaster ELISA, WB 宿主: 小鼠 Monoclonal 3G8 unconjugated
产品编号 ABIN969211
发货至: 中国
  • 抗原 See all IHOG products
    IHOG (Interference Hedgehog (IHOG))
    适用
    Drosophila melanogaster
    宿主
    小鼠
    克隆类型
    单克隆
    应用范围
    ELISA, Western Blotting (WB)
    纯化方法
    purified
    免疫原
    Purified recombinant fragment of human IHOG expressed in E. coli.
    克隆位点
    3G8
    亚型
    IgG1
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    4°C, -20°C for long term storage
  • McLellan, Yao, Zheng, Geisbrecht, Ghirlando, Beachy, Leahy: "Structure of a heparin-dependent complex of Hedgehog and Ihog." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 46, pp. 17208-13, (2006) (PubMed).

  • 抗原
    IHOG (Interference Hedgehog (IHOG))
    别名
    IHOG
    别名
    CG9211 antibody, CT26314 antibody, Dmel\\CG9211 antibody, Ihog antibody, iHog antibody, interference hedgehog antibody, ihog antibody
    背景

    Description: The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cells, encodes a type 1 membrane protein shown here to bind and to mediate response to the active Hedgehog (Hh) protein signal. ihog mutations produce defects characteristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog action at or upstream of the negatively acting receptor component, Patched (Ptc). The first of two extracellular fibronectin type III (FNIII) domains of the Ihog protein mediates a specific interaction with Hh protein in vitro, but the second FNIII domain is additionally required for in vivo signaling activity and for Ihog-enhanced binding of Hh protein to cells coexpressing Ptc. Other members of the Ihog family, including Drosophila Boi and mammalian CDO and BOC, also interact with Hh ligands via a specific FNIII domain, thus identifying an evolutionarily conserved family of membrane proteins that function in Hh signal response.

    Aliases: CG9211, CT26314, Dmel\CG9211, ihog, Ihog

    分子量
    98 kDa
    基因ID
    33972
    HGNC
    33972
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