NEIL1 Protein (AA 2-390) (His-SUMO Tag)
-
- 抗原 See all NEIL1 蛋白
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 2-390
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This NEIL1 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- PEGPELHLAS QFVNEACRAL VFGGCVEKSS VSRNPEVPFE SSAYRISASA RGKELRLILS PLPGAQPQQE PLALVFRFGM SGSFQLVPRE ELPRHAHLRF YTAPPGPRLA LCFVDIRRFG RWDLGGKWQP GRGPCVLQEY QQFRENVLRN LADKAFDRPI CEALLDQRFF NGIGNYLRAE ILYRLKIPPF EKARSVLEAL QQHRPSPELT LSQKIRTKLQ NPDLLELCHS VPKEVVQLGG RGYGSESGEE DFAAFRAWLR CYGMPGMSSL QDRHGRTIWF QGDPGPLAPK GRKSRKKKSK ATQLSPEDRV EDALPPSKAP SRTRRAKRDL PKRTATQRPE GTSLQQDPEA PTVPKKGRRK GRQAASGHCR PRKVKADIPS LEPEGTSAS
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product NEIL1 蛋白
-
Endonuclease VIII-Like 1 (NEIL1) (AA 302-390) protein (GST tag)
NEIL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Endonuclease VIII-Like 1 (NEIL1) (AA 200-390) protein (His tag)NEIL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Endonuclease VIII-Like 1 (NEIL1) (AA 1-390) protein (His tag)NEIL1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Endonuclease VIII-Like 1 (NEIL1) (AA 1-390) protein (GST tag)NEIL1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Endonuclease VIII-Like 1 (NEIL1) (AA 2-390) protein (His tag)Crystallography grade NEIL1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Endonuclease VIII-Like 1 (NEIL1) (AA 2-389) protein (His tag)Crystallography grade NEIL1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Endonuclease VIII-Like 1 (NEIL1) protein (Myc-DYKDDDDK Tag)NEIL1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- 抗原
- NEIL1 (Endonuclease VIII-Like 1 (NEIL1))
- 别名
- NEIL1 (NEIL1 产品)
- 别名
- FPG1 Protein, NEI1 Protein, hFPG1 Protein, 2810450N13Rik Protein, Nei1 Protein, nei-like DNA glycosylase 1 Protein, nei like DNA glycosylase 1 Protein, nei endonuclease VIII-like 1 (E. coli) Protein, Neil1 Protein, NEIL1 Protein
- 背景
- Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and roves damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the roved base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
- 分子量
- 59.6 kDa
- UniProt
- Q96FI4
- 途径
- DNA Damage Repair
-
