MAP2K6 Protein (AA 1-334, full length) (His-SUMO Tag)
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- 抗原 See all MAP2K6 蛋白
- MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
- 蛋白类型
- Recombinant
- 产品特性
- full length, AA 1-334
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This MAP2K6 protein is labelled with His-SUMO Tag.
- 应用范围
- SDS-PAGE (SDS)
- 序列
- MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIMELG RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV KPSNVLINAL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSAEFVDF TSQCLKKNSK ERPTYPELMQ HPFFTLHESK GTDVASFVKL ILGD
- 纯化方法
- SDS-PAGE
- 纯度
- > 90 %
- Top Product
- Discover our top product MAP2K6 蛋白
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Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) (Active) protein (GST tag)
MAP2K6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (Lys82Ala-Mutant) (Active) protein (GST tag)MAP2K6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (Ser207Asp-Mutant), (Thr211Asp-Mutant) (Active) protein (His-GST)MAP2K6 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 6-334) protein (His tag)MAP2K6 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) protein (GST tag)MAP2K6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-334) protein (GST tag)MAP2K6 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) protein (GST tag,His tag)MAP2K6 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 80 % as determined by reducing SDS-PAGE.
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (Active) protein (GST tag,His tag)MAP2K6 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 88 % as determined by reducing SDS-PAGE. Active
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) protein (Strep Tag)Crystallography grade MAP2K6 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) protein (Strep Tag)Crystallography grade MAP2K6 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.1-2 mg/mL
- 缓冲液
- 20 mM Tris-HCl based buffer, pH 8.0
- 储存条件
- -80 °C,4 °C,-20 °C
- 储存方法
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- 抗原
- MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
- 别名
- MP2K6 (MAP2K6 产品)
- 别名
- MAPKK6 Protein, MEK6 Protein, MKK6 Protein, PRKMK6 Protein, SAPKK-3 Protein, SAPKK3 Protein, Mkk6 Protein, Prkmk6 Protein, MKK3 Protein, map2k3 Protein, zMKK3 Protein, map2k6 Protein, mitogen-activated protein kinase kinase 6 Protein, mitogen-activated protein kinase kinase 6 L homeolog Protein, MAP2K6 Protein, Map2k6 Protein, map2k6 Protein, map2k6.L Protein
- 背景
- Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases
- 分子量
- 53.47 kDa
- UniProt
- P52564
- 途径
- MAPK Pathway, TLR signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
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