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IL23R Protein (AA 24-372) (Fc Tag)

IL23R 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func
产品编号 ABIN4949177
发货至: 中国
  • 抗原 See all IL23R 蛋白
    IL23R (Interleukin 23 Receptor (IL23R))
    蛋白类型
    Recombinant
    产品特性
    AA 24-372
    宿主
    • 16
    • 7
    • 2
    • 2
    • 1
    小鼠
    资源
    • 12
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This IL23R protein is labelled with Fc Tag.
    应用范围
    Functional Studies (Func)
    序列
    AA 24-372
    产品特性
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 66.8 kDa. As a result of glycosylation, the protein migrates as 90-100 kDa under reducing (R) condition, and 180-200 kDa under non-reducing (NR) condition (SDS-PAGE).
    纯度
    >95 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product IL23R 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
  • 抗原
    IL23R (Interleukin 23 Receptor (IL23R))
    别名
    IL-23R (IL23R 产品)
    别名
    IL-23R Protein, IL23R Protein, il-23r Protein, interleukin 23 receptor Protein, IL23R Protein, il23r Protein, Il23r Protein
    背景
    Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
    分子量
    66.8 kDa
    NCBI登录号
    NP_653131
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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