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Glycoprotein / GP (Virus) (AA 23-700) protein (Fc Tag)

宿主: Human Herpesvirus 5 (HHV-5) 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
产品编号 ABIN2870783
发货至: 中国
  • 抗原
    Glycoprotein / GP (Virus)
    蛋白类型
    Recombinant
    产品特性
    AA 23-700
    宿主
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    Human Herpesvirus 5 (HHV-5)
    资源
    • 9
    HEK-293 Cells
    标记
    Fc Tag
    序列
    AA 23-700
    产品特性
    This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 104 kDa. The protein migrates as 140-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    纯度
    >90 % as determined by SDS-PAGE.
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
  • 抗原
    Glycoprotein / GP (Virus)
    物质类
    Viral Protein
    背景
    Human cytomegalovirus is a species of the Cytomegalovirus genus of viruses, which in turn is a member of the viral family known as Herpesviridae or herpesviruses. It is typically abbreviated as HCMV or, commonly but more ambiguously, as CMV. CMV Virus Envelope Glycoportein B (CMV-GB) can be cleaved into glycoprotein GP55. Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. CMV-GB may be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Furthermore, CMV-GB can interact with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also, CMV-GB participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
    分子量
    104.0 kDa
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