Glycoprotein / GP (Virus) (AA 33-637) protein (His tag)
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- 抗原
- Glycoprotein / GP (Virus)
- 蛋白类型
- Recombinant
- 产品特性
- AA 33-637
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宿主
- Ebola Virus
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资源
- HEK-293 Cells
- 标记
- His tag
- 序列
- AA 33-637
- 产品特性
- Ebolavirus EBOV(subtype Zaire,strain Kikwit-95) GP, containing GP1 and GP2, is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 67 kDa. The predicted N-terminus is Ile 33. The reducing (R) protein migrates as 21-23 kDa (GP2-delta) and 110-120 kDa (GP1) in SDS-PAGE .
- 纯度
- >85 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Glycoprotein / GP (Virus) (AA 33-304) protein (His tag)
宿主: Ebola Virus 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Glycoprotein / GP (Virus) (AA 67-297) protein (His tag)宿主: Human Respiratory Syncytial Virus (hRSV) 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
Glycoprotein / GP (Virus) (AA 33-501) protein (His tag)宿主: Ebola Virus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Glycoprotein / GP (Virus) (AA 33-324) protein (His tag)宿主: Ebola Virus 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Glycoprotein / GP (Virus) (AA 23-700) protein (Fc Tag)宿主: Human Herpesvirus 5 (HHV-5) 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- Glycoprotein / GP (Virus)
- 物质类
- Viral Protein
- 背景
- EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160- kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
- 分子量
- 67.2 kDa
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