ADAM17 Protein (AA 18-563) (His tag)
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- 抗原 See all ADAM17 蛋白
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
- 蛋白类型
- Recombinant
- 产品特性
- AA 18-563
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This ADAM17 protein is labelled with His tag.
- 序列
- AA 18-563
- 产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 63.4 kDa. The protein migrates as 19 kDa and 20 kDa(Propeptide),55-66 kDa (Mature-ADAM17) and 75-94 kDa(Pro-ADAM17) under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >85 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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- Discover our top product ADAM17 蛋白
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ADAM Metallopeptidase Domain 17 (ADAM17) (AA 752-824) protein (His-IF2DI Tag)
ADAM17 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-314) protein (GST tag)ADAM17 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 693-824) protein (His tag)Crystallography grade ADAM17 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 693-827) protein (His tag)Crystallography grade ADAM17 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-671) protein (His tag)Crystallography grade ADAM17 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-671) protein (His tag)Crystallography grade ADAM17 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-824) protein (rho-1D4 tag)Crystallography grade ADAM17 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
ADAM Metallopeptidase Domain 17 (ADAM17) (AA 215-827) protein (rho-1D4 tag)Crystallography grade ADAM17 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM MES, 150 mM NaCl, pH 6.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))
- 别名
- ADAM17 (ADAM17 产品)
- 别名
- ADAM18 Protein, CD156B Protein, CSVP Protein, NISBD Protein, TACE Protein, CD156b Protein, Tace Protein, adam17 Protein, si:dkey-81b15.2 Protein, adam18 Protein, cd156b Protein, csvp Protein, tace Protein, fc20b01 Protein, wu:fc20b01 Protein, zgc:63886 Protein, ADAM metallopeptidase domain 17 Protein, a disintegrin and metallopeptidase domain 17 Protein, ADAM metallopeptidase domain 17b Protein, ADAM metallopeptidase domain 17 L homeolog Protein, ADAM metallopeptidase domain 17a Protein, ADAM17 Protein, Adam17 Protein, adam17b Protein, adam17.L Protein, adam17a Protein
- 背景
- Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
- 分子量
- 63.4 kDa
- UniProt
- Q9Z0F8
- 途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Response to Growth Hormone Stimulus
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