Notch Signaling

高度保守的Notch信号通路是独一无二的,因为Notch受体及其大多数相应配体(公认的DSL或Delta/Serrate/LAG-2 DSL家族成员)都是附着在细胞表面的跨膜蛋白。因此,Notch信号对相邻细胞之间的相互作用是有限的。

相邻细胞之间的通信至关重要,特别是在细胞的命运和功能尚未确定的早期发展阶段。Notch信号为细胞提供了一种指定自己身份的方法,同时通过侧抑制作用影响相邻细胞的角色和身份。 Notch信号通路的核心包括两个相邻细胞,一个表达DSL家族配体,另一个表达Notch(受体)。当受体与配体相互作用时,两个独立的蛋白酶把North分成为胞外和胞质两部分。ADAM10裂解与其各自配体结合的North余体胞外部分,并被表达细胞的配体吞噬。γ-分泌酶裂解Notch胞质部分。胞质区迁移到细胞核,并在这里与转录因子CSL结合,将其从一个转录阻遏物转化成一个激活物,并上调Notch靶基因的表达。


NOTCH1 - Notch1

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling...   更多...

Notch Antagonists

AP2A1 (Adaptor-Related Protein Complex 2, alpha 1 Subunit):

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles....   更多...
FBXW7 (F-Box and WD Repeat Domain Containing 7): FBXW7 抗体 FBXW7 ELISA试剂盒 FBXW7 蛋白
NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase): NEDD4 抗体   NEDD4 蛋白
SGK1 (serum/glucocorticoid Regulated Kinase 1): SGK1 抗体 SGK1 ELISA试剂盒 SGK1 蛋白

Notch Ligands

DLL1 (delta-Like 1):

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008].   更多...
JAG1 (Jagged 1): JAG1 抗体 JAG1 ELISA试剂盒 JAG1 蛋白
DLL3 (delta Like Protein 3): DLL3 抗体 DLL3 ELISA试剂盒 DLL3 蛋白
DLL4 (delta-Like 4): DLL4 抗体 DLL4 ELISA试剂盒 DLL4 蛋白
JAG2 (Jagged 2): JAG2 抗体 JAG2 ELISA试剂盒 JAG2 蛋白
SRRT (Serrate RNA Effector Molecule Homolog (Arabidopsis)): SRRT 抗体   SRRT 蛋白

Notch Processing

FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme)):

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of...   更多...
LFNG (LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase): LFNG 抗体 LFNG ELISA试剂盒 LFNG 蛋白
MFNG - Manic Fringe: MFNG 抗体 MFNG ELISA试剂盒 MFNG 蛋白
POFUT1 (Protein O-Fucosyltransferase 1): POFUT1 抗体 POFUT1 ELISA试剂盒 POFUT1 蛋白
POGLUT1 (Protein O-Glucosyltransferase 1): POGLUT1 抗体 POGLUT1 ELISA试剂盒 POGLUT1 蛋白
RFNG (RFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase):   RFNG ELISA试剂盒  

Notch Directed Proteases

ADAM10 (ADAM Metallopeptidase Domain 10):

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008].   更多...
APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans)): APH1A 抗体 APH1A ELISA试剂盒  
ADAM17 (ADAM Metallopeptidase Domain 17): ADAM17 抗体 ADAM17 ELISA试剂盒 ADAM17 蛋白
ADAM7 (ADAM Metallopeptidase Domain 7): ADAM7 抗体 ADAM7 ELISA试剂盒 ADAM7 蛋白
aph1b - Aph 1b: aph1b 抗体   aph1b 蛋白
PSEN1 - Presenilin 1: PSEN1 抗体 PSEN1 ELISA试剂盒 PSEN1 蛋白
PSEN2 - Presenilin 2: PSEN2 抗体 PSEN2 ELISA试剂盒 PSEN2 蛋白
PSENEN - Presenilin Enhancer 2 Homolog (C. Elegans): PSENEN 抗体 PSENEN ELISA试剂盒 PSENEN 蛋白

Pathway Agonists

CRB1 (Crumbs Homolog 1 (Drosophila)):

This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis...   更多...
DTX1 - Deltex Homolog 1: DTX1 抗体 DTX1 ELISA试剂盒 DTX1 蛋白
NEURL1B (Neuralized Homolog 1B (Drosophila)): NEURL1B 抗体   NEURL1B 蛋白
CRB2 (Crumbs Homolog 2 (Drosophila)): CRB2 抗体   CRB2 蛋白
CRB3 (Crumbs Homolog 3 (Drosophila)): CRB3 抗体   CRB3 蛋白
DTX3L (Deltex 3-Like (Drosophila)): DTX3L 抗体   DTX3L 蛋白
DTX2 (Deltex Homolog 2 (Drosophila)): DTX2 抗体   DTX2 蛋白
DTX3 - Deltex Homolog 3: DTX3 抗体   DTX3 蛋白
DTX4 - Deltex Homolog 4: DTX4 抗体   DTX4 蛋白
MIB2 (Mindbomb Homolog 2 (Drosophila)): MIB2 抗体 MIB2 ELISA试剂盒 MIB2 蛋白
NEURL (Neuralized Homolog (Drosophila)):     NEURL 蛋白

Transcription Factors

KCNJ5 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 5):

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with...   更多...
MAML1 (Mastermind-Like 1 (Drosophila)): MAML1 抗体   MAML1 蛋白
RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region): RBPJ 抗体   RBPJ 蛋白
NCOR2 (Nuclear Receptor Co-Repressor 2): NCOR2 抗体 NCOR2 ELISA试剂盒  
EP300 - p300: EP300 抗体 EP300 ELISA试剂盒 EP300 蛋白