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FBXW7 抗体

(F-Box and WD Repeat Domain Containing 7 (FBXW7))
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class\; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012].
FBXW7 抗体  (C-Term) FBXW7 抗体  (C-Term) FBXW7 抗体 (C-Term) (ABIN2782955)

FBXW7 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 斑马鱼, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

FBXW7 抗体  (AA 501-600) FBXW7 抗体  (AA 501-600) FBXW7 抗体 (AA 501-600) (ABIN1386103)

FBXW7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

FBXW7 抗体  (AA 599-707) FBXW7 抗体  (AA 599-707) FBXW7 抗体 (AA 599-707) (ABIN527479)

FBXW7 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated

FBXW7 抗体 by 适用

Find FBXW7 抗体 for a variety of species such as anti-Human FBXW7, anti-Mouse FBXW7, anti-Rat FBXW7. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find FBXW7 抗体 validated for a specific application such as WB, IF (p), ELISA, IHC (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find FBXW7 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

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FBXW7 抗体 by 克隆

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Find FBXW7 抗体 with a specific conjugate such as FITC, HRP, Biotin. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular FBXW7 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC
Validations
  • (1)
  • (7)
Cat. No. ABIN2782955
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro)
Validations
  • (2)
  • (3)
Cat. No. ABIN1386103
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (5)
  • (3)
Cat. No. ABIN527479
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN6140535
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
  • (2)
Cat. No. ABIN527477
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7152509
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN565855
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7236560
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IHC (p)
Validations
  • (2)
Cat. No. ABIN961453
Quantity 50 μg
Datasheet Datasheet

Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6747109
Quantity 100 μL
Datasheet Datasheet
Reactivity Hamster, Mouse, Rat
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN6747028
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7183269
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6243654
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN527478
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN952295
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our FBXW7 抗体

Liu, Shi, Li, Chen, Larsson, Lui: "miR‑223‑3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors." in: International journal of oncology, Vol. 50, Issue 2, pp. 356-364, (2016) (PubMed).

Hua, Ding, Yang: "Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease." in: OncoTargets and therapy, Vol. 9, pp. 6573-6579, (2016) (PubMed).

Yumimoto, Akiyoshi, Ueo, Sagara, Onoyama, Ueo, Ohno, Mori, Mimori, Nakayama: "F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner." in: The Journal of clinical investigation, Vol. 125, Issue 2, pp. 621-35, (2015) (PubMed).

Wang, Yang, Liu, Huang, Wang, Chen, Chen: "RBP-J-interacting and tubulin-associated protein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma by activating the p53-Fbxw7 pathway." in: Biochemical and biophysical research communications, Vol. 454, Issue 1, pp. 71-7, (2015) (PubMed).

Wang, Zhang, Zhou, Sun, Zheng, Lu, Gao, Yang, Zhang, Tao, Dou: "Fbxw7 regulates hepatocellular carcinoma migration and invasion via Notch1 signaling pathway." in: International journal of oncology, Vol. 47, Issue 1, pp. 231-43, (2015) (PubMed).

Maskey, Marlin, Kim, Kim, Ong, Li, Tsiokas: "Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length." in: The EMBO journal, Vol. 34, Issue 19, pp. 2424-40, (2015) (PubMed).

Marathe, Liu, Brai, Kaczarowski, Alberi: "Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry." in: Cell death and differentiation, Vol. 22, Issue 11, pp. 1775-84, (2015) (PubMed).

Chen, Wang, Wang, Huang, Zhang: "STAT1 inhibits human hepatocellular carcinoma cell growth through induction of p53 and Fbxw7." in: Cancer cell international, Vol. 15, pp. 111, (2015) (PubMed).

Yokobori, Yokoyama, Mogi, Endoh, Altan, Kosaka, Yamaki, Yajima, Tomizawa, Azuma, Onozato, Miyazaki, Tanaka, Kuwano: "FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs." in: Molecular cancer research : MCR, Vol. 12, Issue 1, pp. 32-7, (2014) (PubMed).

Lin, Hao, Nagata, Xu, Shang, Meng, Sato, Okuno, Varela, Ding, Garg, Liu, Yang, Yin, Shi, Jiang, Gu, Gong, Zhang, Xu, Kalid, Shacham, Ogawa, Wang, Koeffler: "Genomic and molecular characterization of esophageal squamous cell carcinoma." in: Nature genetics, Vol. 46, Issue 5, pp. 467-73, (2014) (PubMed).

Aliases for FBXW7 抗体

F-box and WD repeat domain containing 7 (Fbxw7) 抗体
F-box and WD repeat domain containing 7 (FBXW7) 抗体
F-box and WD repeat domain containing 7 (fbxw7) 抗体
F-box and WD-40 domain protein 7 (Fbxw7) 抗体
1110001A17Rik 抗体
AGO 抗体
cdc4 抗体
CDC4 抗体
Cdc4 抗体
FBW6 抗体
FBW7 抗体
Fbw7 抗体
Fbwd6 抗体
FBX30 抗体
Fbx30 抗体
FBXO30 抗体
Fbxo30 抗体
FBXW6 抗体
Fbxw6 抗体
hAgo 抗体
hCdc4 抗体
SEL-10 抗体
SEL10 抗体
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