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FBXW7 抗体 (C-Term)

Cited in 1 publication. The 兔多克隆 anti-FBXW7 antibody (ABIN2782955) specifically detects FBXW7 in WB 和 IHC. The antibody is reactive with 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马和斑马鱼 samples.

IHC

Host: Rabbit Target Name: GNAS Sample Type: Human Fetal Heart Antibody Dilution: 1. (FBXW7 抗体 (C-Term))

WB Suggested Anti-FBXW7 Antibody Titration: 0. (FBXW7 抗体 (C-Term))

Host: Rabbit Target Name: FBXW7 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1. (FBXW7 抗体 (C-Term))

Host: Rabbit Target Name: FBXW7 Sample Type: 721_B Whole Cell lysates Antibody Dilution: 1ug/ml (FBXW7 抗体 (C-Term))

Rabbit Anti-FBXW7 Antibody Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue Observed Staining: Cytoplasmic in cell bodies and processes of pinealocytes Primary Antibody Concentration: 1:100 Other Working Concentrations: 1/600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0. (FBXW7 抗体 (C-Term))

IHC

7 images

(1 reference)

产品编号 ABIN2782955

发货至: 中国

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Quick Overview for FBXW7 抗体 (C-Term) (ABIN2782955)

抗原

See all FBXW7 抗体

FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

适用

人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, 斑马鱼

宿主

兔

克隆类型

多克隆

标记

This FBXW7 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

抗原表位
15

13

5

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5

5

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3

3

2

2

1

1

1

1

1
C-Term

原理

FBXW7 Antibody - C-terminal region

序列

LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

产品特性

This is a rabbit polyclonal antibody against FBXW7. It was validated on Western Blot.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 501-600) antibody
FBXW7 适用: 人 WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibody
FBXW7 适用: 人 ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-627) antibody
FBXW7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) antibody
FBXW7 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, 斑马鱼, 猴, Drosophila melanogaster, 非洲爪蟾, Hamster, Bat, 小鸡, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 251-300) antibody
FBXW7 适用: 小鼠, 大鼠, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-707) antibody
FBXW7 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-708) antibody
FBXW7 适用: 人 WB, IHC, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D1 unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 279-515) antibody
FBXW7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibody
FBXW7 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 177-208), (N-Term) antibody
FBXW7 适用: 人 WB 宿主: 兔 Polyclonal RB51853 unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

说明

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8100150

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

缓冲液

Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

prevent freeze-thaw cycles

储存条件

4 °C,-20 °C

储存方法

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Gong, Zack, Morris, Lin, Hukkelhoven, Raheja, Tan, Turcan, Veeriah, Meng, Viale, Schumacher, Palmedo, Beroukhim, Chan: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." in: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).
抗原

FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

别名

FBXW7

背景

Background Information: FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Gene Name: F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
Alternative Symbols: AGO, CDC4, FBW6, FBW7, hAgo, FBX30, FBXW6, SEL10, hCdc4, FBXO30, SEL-10
Protein Name: F-box/WD repeat-containing protein 7

分子量

80 kDa

基因ID

55294

NCBI登录号

NP_001013433

UniProt

Q969H0

途径

Notch Signaling, EGFR Signaling Pathway