CD276 Protein (CD276) (AA 29-245) (Fc Tag)
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- 抗原 See all CD276 蛋白
- CD276
- 蛋白类型
- Recombinant
- 产品特性
- AA 29-245
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This CD276 protein is labelled with Fc Tag.
- 序列
- AA 29-245
- 产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CD276 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer." in: The Journal of experimental medicine, Vol. 216, Issue 4, pp. 982-1000, (2019) (PubMed).
: "Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells." in: Cancer cell, Vol. 35, Issue 2, pp. 221-237.e8, (2019) (PubMed).
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Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer." in: The Journal of experimental medicine, Vol. 216, Issue 4, pp. 982-1000, (2019) (PubMed).
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- 抗原
- CD276
- 别名
- B7-H3 (CD276 产品)
- 别名
- sc:d0645 Protein, zgc:158279 Protein, 6030411F23Rik Protein, AU016588 Protein, B7RP-2 Protein, B7h3 Protein, B7H3 Protein, 4Ig-B7-H3 Protein, B7-H3 Protein, CD276 molecule Protein, CD276 molecule S homeolog Protein, CD276 antigen Protein, Cd276 molecule Protein, CD276 Protein, cd276.S Protein, cd276 Protein, Cd276 Protein
- 背景
- B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
- 分子量
- 49.9 kDa
- 途径
- Cancer Immune Checkpoints
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