PCSK9 Protein (AA 35-694) (His tag,AVI tag,Biotin)
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- 抗原 See all PCSK9 蛋白
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 35-694
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This PCSK9 protein is labelled with His tag,AVI tag,Biotin.
- 品牌
- MABSol®,PrecisionAvi
- 序列
- AA 35-694
- 特异性
- Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.
- 产品特性
- This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 74.9 kDa. The protein migrates as 20 kDa and 65 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and proteolytic digestion.
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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- Discover our top product PCSK9 蛋白
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Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) protein (His tag)
PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 35-694) protein (His tag)PCSK9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >97 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 151-811) protein (His tag)PCSK9 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag,AVI tag,Biotin)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by reduced SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (Fc Tag)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag)PCSK9 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 1-678) protein (GST tag)PCSK9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag)PCSK9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 说明
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Ready-to-use AvitagTM biotinylated protein:
The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.
This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled. - 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
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- 抗原
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- 别名
- PCSK9 (PCSK9 产品)
- 别名
- FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein
- 背景
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
- 分子量
- 13.9 kDa and 61.0 kDa
- 基因ID
- 18, 17
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