PCSK9 Protein (AA 35-694) (His tag)
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- 抗原 See all PCSK9 蛋白
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- 蛋白类型
- Recombinant
- 产品特性
- AA 35-694
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This PCSK9 protein is labelled with His tag.
- 原理
- Mouse PCSK9 Protein
- 序列
- Gln35-Gln694
- 产品特性
- Recombinant Mouse PCSK9 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln35-Gln694.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- The affinity constant of 0.61 nM as determined in SPR assay (Biacore T200). See testing image for detail.
- Top Product
- Discover our top product PCSK9 蛋白
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Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) protein (His tag)
PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >97 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 151-811) protein (His tag)PCSK9 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag,AVI tag,Biotin)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by reduced SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (Fc Tag)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag)PCSK9 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 1-678) protein (GST tag)PCSK9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag)PCSK9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-691) (Active) protein (His tag)PCSK9 宿主: 大鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in 20 mM Tris, 150 mM NaCL, 200 mM L-Aginine ( pH 8.2). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- 别名
- PCSK9 (PCSK9 产品)
- 别名
- FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein
- 背景
- Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme encoded by the PCSK9 gene in humans on chromosome 1.The first two PCSK9 inhibitors, alirocumab and evolocumab, were approved as once every two week injections, by the U.S. Food and Drug Administration in 2015 for lowering LDL-particle concentrations when statins and other drugs were not sufficiently effective or poorly tolerated.
- 分子量
- Due to autocatalytic cleavage, the protein release the pro-form (59 kDa) and mature form (14 kDa). Due to glycosylation, the protein migrates to 65-68 kDa (pro-form) and 15kDa (mature form) based on Tris-Bis PAGE result.
- UniProt
- Q80W65
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