PCSK9 Protein (His tag)
-
- 抗原 See all PCSK9 蛋白
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 小鼠
-
资源
- HEK-293 Cells
- 标记
- This PCSK9 protein is labelled with His tag.
- 原理
- Recombinant Mouse PCSK9/NARC1 Protein (His Tag)(Active)
- 序列
- Met 1-Gln 694
- 产品特性
- A DNA sequence encoding the full length of mouse PCSK9 (NP_705793.1) precursor (Met 1-Gln 694) was expressed, with a C-terminal polyhistidine tag.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized mouse PCSK9 at 10 μg/ml (100 μl/well) can bind biotinylated recombinant human LDLR. The EC50 of biotinylated human LDLR is 0.12 μg/ml.
- Top Product
- Discover our top product PCSK9 蛋白
-
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) protein (His tag)
PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 35-694) protein (His tag)PCSK9 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >97 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 151-811) protein (His tag)PCSK9 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (His tag,AVI tag,Biotin)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by reduced SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-692) (Active) protein (Fc Tag)PCSK9 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (Active) protein (His tag)PCSK9 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 97 % as determined by SDS-PAGE Active
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 1-678) protein (GST tag)PCSK9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) (AA 31-691) (Active) protein (His tag)PCSK9 宿主: 大鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 15 mM Tris, 90 mM NaCl, 50 % Glycerol, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- PCSK9 (Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
- 别名
- PCSK9/NARC1 (PCSK9 产品)
- 别名
- FH3 Protein, HCHOLA3 Protein, LDLCQ1 Protein, NARC-1 Protein, NARC1 Protein, PC9 Protein, AI415265 Protein, AI747682 Protein, Narc1 Protein, proprotein convertase subtilisin/kexin type 9 Protein, proprotein convertase subtilisin/kexin type 9 L homeolog Protein, PCSK9 Protein, pcsk9.L Protein, pcsk9 Protein, Pcsk9 Protein
- 背景
-
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons. References
Synonym: Proprotein Convertase Subtilisin/Kexin Type 9, Neural Apoptosis-Regulated Convertase 1, NARC-1, Proprotein Convertase 9, PC9, Subtilisin/Kexin-Like Protease PC9, Pcsk9, Narc1,FH3,HCHOLA3,Narc1
- 分子量
- 72.6 kDa
- NCBI登录号
- NP_705793
-
