FLT3LG Protein (Fc Tag)
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- 抗原 See all FLT3LG 蛋白
- FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人, 小鼠
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资源
- CHO Cells
- 标记
- This FLT3LG protein is labelled with Fc Tag.
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds to human and mouse FLT3 receptor.
- 交叉反应
- 人, 小鼠
- 产品特性
- The receptor-binding domain of human FLT3L (aa1-185) is fused at the N-terminus to the Fc portion of human IgG1.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product FLT3LG 蛋白
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Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) protein (Fc Tag)
FLT3LG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) protein (His tag)FLT3LG 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-189) protein (Fc Tag)FLT3LG 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) protein (mFc-His Tag)FLT3LG 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-185) protein (His tag)FLT3LG 宿主: 人 宿主: Hi-5 Cells Recombinant >90 % as determined by SDS-PAGE.
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 28-189) protein (His tag)FLT3LG 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-181) protein (His tag)FLT3LG 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 1-235) protein (GST tag)FLT3LG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Fms-Related tyrosine Kinase 3 Ligand (FLT3LG) (AA 27-136) protein (GST tag)FLT3LG 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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In vitro and in vivo generation of conventional and plasmacytoid dendritic cells (DC). FLT3L increases in vivo both NK and DC cells numbers in the spleen when mice are injected intraperitoneally with 2 or 10 μg, daily for 10 days (slightly higher effect at 10 μg).
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- In PBS (sterile).
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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- 抗原
- FLT3LG (Fms-Related tyrosine Kinase 3 Ligand (FLT3LG))
- 别名
- FLT3 Ligand (FLT3LG 产品)
- 别名
- Flt3lg Protein, Ly72L Protein, FL Protein, FLT3L Protein, Vegfr3 Protein, fms related tyrosine kinase 3 ligand Protein, FMS-like tyrosine kinase 3 ligand Protein, fms-related tyrosine kinase 4 Protein, fms-related tyrosine kinase 3 ligand Protein, FLT3LG Protein, Flt3l Protein, Flt4 Protein, Flt3lg Protein
- 背景
- FMS-like tyrosine kinase 3 ligand (FLT3L) acts as a growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It binds to FLT3 (CD135) which is found on multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells in mice. FLT3L induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady-state pDC (plasmacytoid dendritic cells) and cDC (classical dendritic cells) development. Deficiency of FLT3L causes a dramatic decrease in DC numbers, whereas increasing its availability increase in DC numbers.
- UniProt
- P49771
- 途径
- RTK signaling
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