SMARCA4 Protein (AA 1448-1569) (His tag,DYKDDDDK Tag)
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- 抗原 See all SMARCA4 蛋白
- SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1448-1569
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This SMARCA4 protein is labelled with His tag,DYKDDDDK Tag.
- 应用范围
- Binding Studies (Bind), Screening Assay (ScA)
- 产品特性
- The peptide corresponding to amino acids 1448-1569 that contains the bromodomain sequences of SMARCA4 (accession number NP_003063.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 20.4 kDa. It shows binding specificity for acetylated H2BK5, H3K14 and H3K9/14.
- Top Product
- Discover our top product SMARCA4 蛋白
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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (AA 1451-1550) protein (GST tag)
SMARCA4 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (AA 1-1647) protein (Strep Tag)Crystallography grade SMARCA4 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (AA 1-1613) protein (Strep Tag)Crystallography grade SMARCA4 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (AA 1448-1569) protein (GST tag)SMARCA4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Bind, ScA
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (AA 362-549) protein (His tag)SMARCA4 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 80 % by SDS - PAGE SDS
SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4) (AA 700-1246), (partial) protein (His tag)SMARCA4 宿主: 人 宿主: 酵母菌 Recombinant > 90 % SDS
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- 应用备注
- Recombinant SMARCA4 / BRG1 (1448-1569) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))
- 别名
- SMARCA4 / BRG1 (SMARCA4 产品)
- 别名
- SMARCA4 Protein, BAF190 Protein, BAF190A Protein, BRG1 Protein, MRD16 Protein, RTPS2 Protein, SNF2 Protein, SNF2L4 Protein, SNF2LB Protein, SWI2 Protein, hSNF2b Protein, brg-1 Protein, Brg1 Protein, HP1-BP72 Protein, SNF2beta Protein, SW1/SNF Protein, b2b692Clo Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Protein, SMARCA4 Protein, Smarca4 Protein
- 背景
- SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), also known as BRG1, is a member of the SWI/SNF family of proteins and is similar to the Brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. SMARCA4 contains bromodomains for interaction with other proteins. The bromodomain functions as a 'reader' of epigenetic histone marks and regulates chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. SMARCA4 is part of the large ATP-dependent chromatin remodeling complex SNF/SWI which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Gene mutation causes Rhabdoid Tumor Predisposition Syndrome Type 2. SMARCA4 functions as a transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. It also interacts with glucocorticoid receptor (GR), TOPBP1 and progesterone receptor (PR) and is a component of the BAF53 complex which acetylates histone H4 and H2A within nucleosomes. Somatic mutations of SMARCA4 have been detected in some cancer cell lines and loss of SMARCA4 is associated with decreased survival in cancer patients.
- 分子量
- 20.4 kDa
- 途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance
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