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SMARCA4 产品

(SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 4 (SMARCA4))
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].

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Featured SMARCA4 Categories

SMARCA4 抗体

High quality antibodies with extensive validation data.

SMARCA4 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

SMARCA4 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SMARCA4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF, IHC (p), CUT&RUN
Validations
  • (2)
  • (1)
Cat. No. ABIN6991990
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, IP
Validations
  • (5)
Cat. No. ABIN3022959
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF, IP
Validations
  • (6)
Cat. No. ABIN2451926
Quantity 100 μg
Datasheet Datasheet

Recommended SMARCA4 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975082
Quantity 96 tests
Datasheet Datasheet

Recommended SMARCA4 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320623
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3095552
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3134977
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SMARCA4 Products

Zhang, Geng, Liu, Li, Gao, Liu, Fang, Chang: "Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1." in: Molecular metabolism, Vol. 6, Issue 1, pp. 138-147, (2018) (PubMed).

Singh, Foley, Rubino, Boyle, Tandon, Shah, Archer: "Brg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest." in: Molecular and cellular biology, Vol. 36, Issue 15, pp. 1990-2010, (2016) (PubMed).

Chen, Han, Wei, Zhang, Shi, Duan, Li, Zhou, Pu, Zhang, Kang: "SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma." in: Scientific reports, Vol. 5, pp. 8588, (2015) (PubMed).

Jelinic, Schlappe, Conlon, Tseng, Olvera, Dao, Mueller, Hussein, Soslow, Levine: "Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 29, Issue 1, pp. 60-6, (2015) (PubMed).

Singh, Archer: "Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation." in: Nucleic acids research, Vol. 42, Issue 5, pp. 2958-75, (2014) (PubMed).

Miyamoto, Pasque, Jullien, Gurdon: "Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes." in: Genes & development, Vol. 25, Issue 9, pp. 946-58, (2011) (PubMed).

Goldman, Garlick, Kingston: "Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z." in: The Journal of biological chemistry, Vol. 285, Issue 7, pp. 4645-51, (2010) (PubMed).

Ohkawa, Harada, Nakamura, Yoshimura, Tachibana: "Production of a rat monoclonal antibody against Brg1." in: Hybridoma (2005), Vol. 28, Issue 6, pp. 463-6, (2009) (PubMed).

de la Serna, Ohkawa, Higashi, Dutta, Osias, Kommajosyula, Tachibana, Imbalzano: "The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes." in: The Journal of biological chemistry, Vol. 281, Issue 29, pp. 20233-41, (2006) (PubMed).

Synonyms and alternative names related to SMARCA4

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (Smarca4), b2b692Clo, BAF190, BAF190A, brg-1, BRG1, Brg1, HP1-BP72, hSNF2b, MRD16, RTPS2, SMARCA4, SNF2, SNF2beta, SNF2L4, SNF2LB, SW1/SNF, SWI2

Protein level used designations for SMARCA4

  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4
  • transcription activator BRG1-like
  • ATP-dependent helicase SMARCA4
  • BRG1-associated factor 190A
  • BRM/SWI2-related gene 1
  • SNF2-beta
  • SNF2-like 4
  • brahma protein-like 1
  • global transcription activator homologous sequence
  • homeotic gene regulator
  • mitotic growth and transcription activator
  • nuclear protein GRB1
  • protein BRG-1
  • protein brahma homolog 1
  • sucrose nonfermenting-like 4
  • transcription activator BRG1
  • BAF190A
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4
  • SWI/SNF related transcriptional activator
  • WI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
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