BRD2 Protein (AA 344-455) (His tag,DYKDDDDK Tag)
-
- 抗原 See all BRD2 蛋白
- BRD2 (Bromodomain Containing 2 (BRD2))
- 蛋白类型
- Recombinant
- 产品特性
- AA 344-455
-
宿主
- 人
-
资源
- 大肠杆菌（E. Coli）
- 标记
- This BRD2 protein is labelled with His tag,DYKDDDDK Tag.
- 应用范围
- Binding Studies (Bind), Screening Assay (ScA)
- 产品特性
- The peptide corresponding to amino acids 344 - 455 that contains the bromodomain sequences of BRD2 (accession number NM_005104.3) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 19.4 kDa. It shows binding specificity for acetylated H4K5/K8, H4K12, H4K8/K12, H4K12/K16, H4K12/K16/K20 and H4K5/K8/K12/K16.
- Top Product
- Discover our top product BRD2 蛋白
-
Bromodomain Containing 2 (BRD2) (AA 65-187) protein (His tag)
BRD2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Bromodomain Containing 2 (BRD2) (AA 167-256) protein (GST tag)BRD2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bromodomain Containing 2 (BRD2) (AA 1-455) protein (His tag)BRD2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Bromodomain Containing 2 (BRD2) (AA 1-801) protein (GST tag)BRD2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Bromodomain Containing 2 (BRD2) (AA 1-801) protein (Strep Tag)Crystallography grade BRD2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Bromodomain Containing 2 (BRD2) (AA 1-798) protein (Strep Tag)Crystallography grade BRD2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Bromodomain Containing 2 (BRD2) (AA 71-194) protein (His tag,DYKDDDDK Tag)BRD2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Bind, ScA
-
- 应用备注
- Recombinant BRD2 (344-455) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
- 限制
- 仅限研究用
-
- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
-
- 抗原
- BRD2 (Bromodomain Containing 2 (BRD2))
- 别名
- BRD2 (BRD2 产品)
- 别名
- D6S113E Protein, FSH Protein, FSRG1 Protein, NAT Protein, RING3 Protein, RNF3 Protein, AW228947 Protein, D17H6S113E Protein, Frg-1 Protein, Fsrg-1 Protein, Fsrg1 Protein, Nat Protein, Ring3 Protein, Rnf3 Protein, mKIAA4005 Protein, brd2-a Protein, fsh Protein, fsrg1 Protein, nat Protein, ring3 Protein, rnf3 Protein, brd2 Protein, fe47f02 Protein, fi85h05 Protein, wu:fe47f02 Protein, wu:fi85h05 Protein, Ring3 protein Protein, bromodomain containing 2 Protein, bromodomain containing 2 S homeolog Protein, bromodomain containing 2a Protein, CHLREDRAFT_190116 Protein, CHLREDRAFT_150233 Protein, CHLREDRAFT_182576 Protein, CHLREDRAFT_188250 Protein, BRD2 Protein, Brd2 Protein, brd2.S Protein, brd2a Protein
- 背景
- Bromodomain-containing protein 2 (BRD2), also known as RING3, belongs to the BET subclass of proteins, which are characterized by two N-terminal bromodomains and one ET (Extra Terminal) domain. BRDs associate with chromatin through their bromodomains that recognize acetylated histone lysine residues. Bromodomains function as 'readers' of these epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. The ET domain functions as a protein binding motif and exerts atypical serine-kinase activity. The BET family consists of at least four members in mouse and human, BRD2 (also referred to as FSRG1, RING3), BRD3 (FSRG2, ORFX), BRD4 (FSRG4, MCAP/HUNK1), and BRDT (FSRG3, BRD6). BRD proteins are related to the female sterile homeotic protein gene in Drosophila, a gene required maternally for proper expression of other homeotic genes, such as Ubx, which is involved in pattern formation. BRD2 causes elevated protein kinase activity in leukemias. Transgenic mice overexpressing BRD2 in the lymphoid system develop diffuse large-cell lymphoma. BRD2 has been shown to interact with E2F1 and with histone H4 acetylated at Lys12 via its two bromodomains. BRD2 may play a role in spermatogenesis or folliculogenesis. Genetic evidence links the BRD2 gene to both juvenile myoclonic epilepsy and photoparoxysomal responses.
- 分子量
- 19.4 kDa
- 途径
- Chromatin Binding, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
-
