LGALS1/Galectin 1 Protein (AA 2-135, N-Term)
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- 抗原 See all LGALS1/Galectin 1 (LGALS1) 蛋白
- LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 2-135, N-Term
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宿主
- 人
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资源
- CHO Cells
- 应用范围
- Flow Cytometry (FACS)
- 纯度
- > 95 % , as determined by Coomassie stained SDS-PAGE.
- 过滤
- 0.22 μm filtered
- Top Product
- Discover our top product LGALS1 蛋白
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Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (Fc Tag)
LGALS1 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (His tag)Crystallography grade LGALS1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (Fc Tag)LGALS1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-135) protein (GST tag)LGALS1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 1-100) protein (GST tag)LGALS1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Lectin, Galactoside-Binding, Soluble, 1 (LGALS1) (AA 2-135) protein (His tag)Crystallography grade LGALS1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Biological activity: Recombinant human Galectin-1 is able to agglutinate human red blood cells with an ED50 of 0.2 - 1.0 μg/ml.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 溶解方式
- For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 μg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1 % BSA or HSA. After dilution, the cytokine can be stored between 2 °C and 8 °C for one month or from -20 °C to -70 °C for up to 3 months.
- 缓冲液
- 0.22 μm filtered protein solution is in 10 mM NaH2PO4, 0.3M NaCl, 2 mM β-mercaptoethanol, pH 7.2.
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Unopened vial can be stored between 2°C and 8°C for three months, at -20°C for six months, or at -70°C for one year.
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- 抗原
- LGALS1/Galectin 1 (LGALS1) (Lectin, Galactoside-Binding, Soluble, 1 (LGALS1))
- 别名
- Galectin-1 (LGALS1 产品)
- 别名
- GAL1 Protein, GBP Protein, Galectin-1 Protein, LGAS1 Protein, LGALS1 Protein, MGC64502 Protein, GB10026 Protein, AA410090 Protein, Gal-1 Protein, Galbp Protein, L-14.5 Protein, L14 Protein, Lect14 Protein, galectin-1 Protein, Galaptin Protein, galectin 1 Protein, galectin-1 Protein, lectin, galactoside-binding, soluble, 1 L homeolog Protein, protein enabled Protein, lectin, galactose binding, soluble 1 Protein, LGALS1 Protein, Lgals1 Protein, CC1G_05003 Protein, CC1G_05004 Protein, lgals1.L Protein, LOC408848 Protein
- 背景
- Galectin-1 is a 14 kD lectin widely expressed in mammals and produced by vascular, interstitial, epithelial, and immune cells. This protein binds specifically to galactoside derivatives of glycoproteins on cell membranes. A great number of membrane glycoconjugates have been identified as binding partners of Galectin-1 such as β1 integrins, CD2, CD3, CD4, CD43, CD45, and GM1 ganglioside. Galectin-1 also binds to a number of extracellular-matrix components, such as laminin and fibronectin in a dose-dependent and β-galactoside-dependent manner. Because Galectin-1 is a divalent lectin, it can also form complexes with receptor partners participating in cell-matrix recognition. Thus, Galectin-1 is involved in a variety of biological activities such as cell-matrix interactions, immune responses, inflammatory responses, tumorigenesis, and apoptosis of both tumor and immune cells. In addition, Galectin-1 is thought to play a role in creating immune tolerance in pregnancy. Galectin-1 induces the differentiation of dendritic cells towards a phenotype which dampens T helper 1 cells and T helper 17 cells and dampens inflammation via IL-10 and IL-27. It also plays a role in the formation and expression of HLA-G in the syncytium. Galectin-1 may act as an autocrine negative growth factor that regulates cell proliferation.
- 分子量
- This 155 amino acid recombinant protein has a predicted molecular mass of approximately 16.8 kDa. The protein migrates at approximately 24 kDa by SDS-PAGE in DTT-reducing conditions. The N-terminal amino acid is His.
- 途径
- Carbohydrate Homeostasis
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