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IL-33 Protein (AA 1-270) (His tag)

IL33 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant ~95 % WB, ELISA, MS, Neut
产品编号 ABIN2468679
发货至: 中国
  • 抗原 See all IL-33 (IL33) 蛋白
    IL-33 (IL33) (Interleukin 33 (IL33))
    蛋白类型
    Recombinant
    产品特性
    AA 1-270
    宿主
    • 22
    • 15
    • 4
    • 2
    • 1
    • 1
    • 1
    资源
    • 30
    • 8
    • 2
    • 2
    • 1
    大肠杆菌(E. Coli)
    标记
    This IL-33 protein is labelled with His tag.
    应用范围
    Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)
    纯度
    ~95 %
    Top Product
    Discover our top product IL33 蛋白
  • 应用备注
    This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    100 mM sodium phosphate, 500 mM NaCl, 25 mM imidazole, 10 % gycerol
    注意事项
    Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
    储存条件
    -80 °C
    储存方法
    Store in working aliquots at -70 °C.
  • 抗原
    IL-33 (IL33) (Interleukin 33 (IL33))
    别名
    IL-33 (IL33 产品)
    别名
    IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
    背景
    Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1???, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-?B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5).
    分子量
    30 kDa (Calculated)
    基因ID
    90865
    NCBI登录号
    NP_254274
    OMIM
    15559209
    UniProt
    O95760
    途径
    Production of Molecular Mediator of Immune Response
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