IL-33 Protein (AA 1-270) (His tag)
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- 抗原 See all IL-33 (IL33) 蛋白
- IL-33 (IL33) (Interleukin 33 (IL33))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-270
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This IL-33 protein is labelled with His tag.
- 应用范围
- Western Blotting (WB), ELISA, Mass Spectrometry (MS), Neutralization (Neut)
- 纯度
- ~95 %
- Top Product
- Discover our top product IL33 蛋白
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- 应用备注
- This recombinant protein can be used for WB, ELISA, MS and neutralization assays.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 100 mM sodium phosphate, 500 mM NaCl, 25 mM imidazole, 10 % gycerol
- 注意事项
- Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- 储存条件
- -80 °C
- 储存方法
- Store in working aliquots at -70 °C.
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- 抗原
- IL-33 (IL33) (Interleukin 33 (IL33))
- 别名
- IL-33 (IL33 产品)
- 别名
- IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
- 背景
- Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1???, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-?B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5).
- 分子量
- 30 kDa (Calculated)
- 基因ID
- 90865
- NCBI登录号
- NP_254274
- OMIM
- 15559209
- UniProt
- O95760
- 途径
- Production of Molecular Mediator of Immune Response
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