IL-33 Protein (AA 112-270)
(2 references)-
- 抗原 See all IL-33 (IL33) 蛋白
- IL-33 (IL33) (Interleukin 33 (IL33))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 112-270
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds to human ST2.
- 交叉反应
- 人
- 产品特性
- Human IL-33 (aa 112-270) is untagged.
- 纯度
- >95 % (SDS-PAGE)
- 内毒素水平
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product IL33 蛋白
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Interleukin 33 (IL33) (AA 112-270) protein
IL33 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 33 (IL33) (AA 109-270) (Active) protein (His tag)IL33 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 33 (IL33) (AA 109-270) protein (His tag)IL33 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 33 (IL33) (AA 109-264) protein (His tag)IL33 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 33 (IL33) (AA 1-270) protein (GST tag)IL33 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 33 (IL33) (AA 171-269) protein (GST tag)IL33 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 33 (IL33) protein (His tag)IL33 宿主: 猕猴 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.
Interleukin 33 (IL33) (AA 1-270) protein (Strep Tag)Crystallography grade IL33 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Interleukin 33 (IL33) (AA 1-266) protein (Strep Tag)Crystallography grade IL33 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Activates human ST2-dependent NF-kappaB pathway.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute with 100 μL sterile water.
- 浓度
- Lot specific
- 缓冲液
- Lyophilized. Contains PBS.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - 有效期
- 6 months
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: "Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 9, pp. 5254-60, (2011) (PubMed).
: "An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 5981-9, (2008) (PubMed).
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: "Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 9, pp. 5254-60, (2011) (PubMed).
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- 抗原
- IL-33 (IL33) (Interleukin 33 (IL33))
- 别名
- IL-33 (IL33 产品)
- 别名
- IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
- 背景
- Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
- 分子量
- ~18kDa
- UniProt
- Q2YEJ5
- 途径
- Production of Molecular Mediator of Immune Response
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