IL-33 Protein (AA 112-270) (His tag)
(3 references)-
- 抗原 See all IL-33 (IL33) 蛋白
- IL-33 (IL33) (Interleukin 33 (IL33))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 112-270
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This IL-33 protein is labelled with His tag.
- 应用范围
- SDS-PAGE (SDS)
- 特异性
- Binds to human ST2.
- 交叉反应
- 人
- 产品特性
- Human IL-33 (aa 112-270) is fused at the C-terminus to a His-tag.
- 纯度
- >90 % (SDS-PAGE)
- 过滤
- 0.2 μm filtered
- 内毒素水平
- <1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product IL33 蛋白
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Interleukin 33 (IL33) (AA 112-270) protein
IL33 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 33 (IL33) (AA 109-270) (Active) protein (His tag)IL33 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 33 (IL33) (AA 109-270) protein (His tag)IL33 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 33 (IL33) (AA 109-264) protein (His tag)IL33 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 33 (IL33) (AA 1-270) protein (GST tag)IL33 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 33 (IL33) (AA 171-269) protein (GST tag)IL33 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interleukin 33 (IL33) protein (His tag)IL33 宿主: 猕猴 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by reducing SDS-PAGE.
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Activates human ST2-dependent NF-kappaB pathway.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. - 有效期
- 3 months
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: "Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 88, Issue 11, pp. 1245-53, (2008) (PubMed).
: "An IL-1 cytokine member, IL-33, induces human basophil activation via its ST2 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 9, pp. 5981-9, (2008) (PubMed).
: "IL-33 can promote survival, adhesion and cytokine production in human mast cells." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 87, Issue 10, pp. 971-8, (2007) (PubMed).
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: "Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 88, Issue 11, pp. 1245-53, (2008) (PubMed).
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- 抗原
- IL-33 (IL33) (Interleukin 33 (IL33))
- 别名
- IL-33 (IL33 产品)
- 别名
- IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
- 背景
- Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL33 is converted by CASP1 to a 18 kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
- 分子量
- ~18kDa (SDS-PAGE)
- UniProt
- Q2YEJ5
- 途径
- Production of Molecular Mediator of Immune Response
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