IL-37 Protein (AA 46-218) (His tag)
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- 抗原 See all IL-37 (IL37) 蛋白
- IL-37 (IL37) (Interleukin 37 (IL37))
- 蛋白类型
- Recombinant
- 产品特性
- AA 46-218
- 宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This IL-37 protein is labelled with His tag.
- 序列
- AA 46-218
- 产品特性
- This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.3 kDa. The protein migrates as 20.3 kDa under reducing (R) condition (SDS-PAGE).
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IL37 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
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- 抗原
- IL-37 (IL37) (Interleukin 37 (IL37))
- 别名
- IL-37 (IL37 产品)
- 别名
- FIL1 Protein, FIL1(ZETA) Protein, FIL1Z Protein, IL-1F7 Protein, IL-1H Protein, IL-1H4 Protein, IL-1RP1 Protein, IL-37 Protein, IL1F7 Protein, IL1H4 Protein, IL1RP1 Protein, interleukin 37 Protein, IL37 Protein
- 背景
- Interleukin-1 family member 7 (IL1F7b) ,a member of the IL-1 family, is aslo known as interleukin-37, interleukin-1 homolog 4 (IL-1H4), interleukin-1 zeta (IL-1 zeta) and interleukin-1-related protein, which can interact with SMAD3 and bind to IL18R1, but not to IL1R1, with lower affinity than IL18. IL1F7b is a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Therefore,IL1F7b can suppress, or reduce, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spare anti-inflammatory cytokines. Furthermore,IL1F7b can also inhibit dendritic cell activation.
- 分子量
- 20.3 kDa
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