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IL-37 Protein (AA 46-218) (His tag)

IL37 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant >95 % (SDS-PAGE) SDS
产品编号 ABIN1344168
发货至: 中国
  • 抗原 See all IL-37 (IL37) 蛋白
    IL-37 (IL37) (Interleukin 37 (IL37))
    蛋白类型
    Recombinant
    产品特性
    AA 46-218
    宿主
    资源
    • 7
    • 1
    • 1
    • 1
    大肠杆菌(E. Coli)
    标记
    This IL-37 protein is labelled with His tag.
    应用范围
    SDS-PAGE (SDS)
    交叉反应
    产品特性
    Human IL-37 (aa Val46-Asp218) is fused at the C-terminus to a His-tag.
    纯度
    >95 % (SDS-PAGE)
    过滤
    0.2 μm filtered
    内毒素水平
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IL37 蛋白
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Reconstitute in distilled water.
    浓度
    Lot specific
    缓冲液
    Lyophilized from 0.2μm-filtered solution in 55 mM TRIS-Cl, pH 8.2, containing 150 mM NaCl.
    储存条件
    4 °C,-20 °C
    储存方法
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
    有效期
    6 months
  • 抗原
    IL-37 (IL37) (Interleukin 37 (IL37))
    别名
    IL-37 (IL37 产品)
    别名
    FIL1 Protein, FIL1(ZETA) Protein, FIL1Z Protein, IL-1F7 Protein, IL-1H Protein, IL-1H4 Protein, IL-1RP1 Protein, IL-37 Protein, IL1F7 Protein, IL1H4 Protein, IL1RP1 Protein, interleukin 37 Protein, IL37 Protein
    背景
    IL-37 (IL-1F7, IL-1H4) is an IL-1 family member that is expressed only in certain types of human organs and cells such as heart, thymus, testis, kidney, mononuclear cells (PBMCs) and dendritic cells. IL-37 is an inhibitor of innate immunity with anti-inflammatory properties. It binds to the interleukin-18 receptor (IL-18R) and its co-receptor SIGIRR. IL-37 is secreted as a full-length and as a processed form starting from amino acid Val46. It plays an important role as a link between innate and adaptive immunity and acts as an inhibitor of autoimmune diseases and tumor growth. IL-37 also inhibited Lipopolysaccharide (LPS)-induced immunological reaction and LPS-induced osteoclast formation and bone resorption.
    分子量
    ~20kDa (SDS-PAGE)
    UniProt
    Q9NZH6
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