E-cadherin Protein (AA 23-621) (Fc Tag)
(3 references)-
- 抗原 See all E-cadherin (CDH1) 蛋白
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 23-621
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This E-cadherin protein is labelled with Fc Tag.
- 序列
- AA 23-621
- 产品特性
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 92.4 kDa. As a result of different glycosylation, the protein migrates as 110-125 kDa Cadherin, a 48 kDa Propeptide under reducing (R) condition, and 200-250 kDa under non-reducing (NR) condition (SDS-PAGE).
- 纯度
- >95 % as determined by SDS-PAGE.
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CDH1 蛋白
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Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 1-882) protein (GST tag)
CDH1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 381-480) protein (GST tag)CDH1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (AA 155-707) protein (His tag)CDH1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) protein (Fc Tag)CDH1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 75 % as determined by SDS-PAGE
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) (Active) protein (His tag)CDH1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1) protein (His tag)CDH1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- 50 mM Tris, 100 mM Glycine, pH 7.5
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- Lyophilized Protein should be stored at -20 °C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20 °C or -70 °C. Avoid repeated freeze-thaw cycles.
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: "An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins." in: Cellular microbiology, Vol. 21, Issue 2, pp. e12949, (2019) (PubMed).
: "PAK2 links cell survival to mechanotransduction and metabolism." in: The Journal of cell biology, Vol. 218, Issue 6, pp. 1958-1971, (2019) (PubMed).
: "E-cadherin mediated lateral interactions between neighbor cells necessary for collective migration." in: Journal of biomechanics, Vol. 71, pp. 159-166, (2019) (PubMed).
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: "An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins." in: Cellular microbiology, Vol. 21, Issue 2, pp. e12949, (2019) (PubMed).
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- 抗原
- E-cadherin (CDH1) (Cadherin 1, Type 1, E-Cadherin (Epithelial) (CDH1))
- 别名
- E-Cadherin (CDH1 产品)
- 别名
- Arc-1 Protein, CD324 Protein, CDHE Protein, ECAD Protein, LCAM Protein, UVO Protein, E-cadherin Protein, cdh1 Protein, si:dz180o5.2 Protein, uvo Protein, lcam Protein, E-Cad Protein, XBcad Protein, l-cam Protein, xcdh1 Protein, cdhc-A Protein, xb-cad Protein, XTCAD-1 Protein, c-cadherin Protein, cadherin-1 Protein, uvomorulin Protein, XB-cadherin Protein, arc-1 Protein, cd324 Protein, cdhe Protein, ecad Protein, AA960649 Protein, E-cad Protein, Ecad Protein, L-CAM Protein, Um Protein, cadherin 1 Protein, si:busm1-180o5.2 Protein, cadherin 1, type 1, E-cadherin (epithelial) Protein, cadherin 1, type 1 S homeolog Protein, CDH1 Protein, si:busm1-180o5.2 Protein, cdh1 Protein, Cdh1 Protein, cdh1.S Protein
- 背景
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells, cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
- 分子量
- 92.3 kDa
- 途径
- WNT signaling, Sensory Perception of Sound, Cell-Cell Junction Organization, Tube Formation
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