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PLAU Protein (AA 21-431) (His tag)

PLAU 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE.
产品编号 ABIN2181654
发货至: 中国
  • 抗原 See all PLAU 蛋白
    PLAU (Plasminogen Activator, Urokinase (PLAU))
    蛋白类型
    Recombinant
    产品特性
    AA 21-431
    宿主
    • 18
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    资源
    • 14
    • 11
    • 6
    • 3
    • 2
    • 1
    HEK-293 Cells
    标记
    This PLAU protein is labelled with His tag.
    序列
    AA 21-431
    产品特性
    Human PLAU, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 45 kDa. The predicted N-terminus is Ser21, Ile179 & Lys156. The reducing (R) protein migrates as four bands corresponding to the short α chain, long α chain, β chain and unprocessed full-length chain with the molecular mass of 20 kDa, 23 kDa, 32 kDa and 50 kDa respectively in SDS-PAGE due to glycosylation and cleavage.
    纯度
    >92 % as determined by SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product PLAU 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    50 mM Sodium Acetate, 100 mM NaCl, pH 5.0
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Ambrosetti, Paoletti, Bosco, Parisse, Scaini, Tagliabue, de Marco, Casalis: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).

  • 抗原
    PLAU (Plasminogen Activator, Urokinase (PLAU))
    别名
    PLAU (PLAU 产品)
    别名
    PLAU Protein, u-PA Protein, ATF Protein, BDPLT5 Protein, QPD Protein, UPA Protein, URK Protein, uPA Protein, UPAM Protein, plasminogen activator, urokinase Protein, urokinase-type plasminogen activator Protein, PLAU Protein, CpipJ_CPIJ002131 Protein, CpipJ_CPIJ006543 Protein, CpipJ_CPIJ013396 Protein, CpipJ_CPIJ013623 Protein, Plau Protein
    背景
    Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys - Pro - Gly - Arg560 - Val561 - Val - Gly - Gly - Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
    分子量
    47.2 kDa
    NCBI登录号
    NP_002649
    途径
    Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration
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