Cathepsin B Protein (CTSB) (AA 18-339) (His tag)
(2 references)-
- 抗原 See all Cathepsin B (CTSB) 蛋白
- Cathepsin B (CTSB)
- 蛋白类型
- Recombinant
- 产品特性
- AA 18-339
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This Cathepsin B protein is labelled with His tag.
- 序列
- AA 18-339
- 产品特性
- rh CTSB is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 36.7 kDa (pro-form) and 29 kDa (mature-form). The predicted N-terminus is Arg18 (pro-form) or Phe74 (mature-form). Due to glycosylation, The reducing (R) protein migrates as 43 kDa (pro-form) band in SDS-PAGE and there may be a 34 kDa (mature-form) band.
- 纯度
- >95 % as determined by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product CTSB 蛋白
-
Cathepsin B (CTSB) (AA 1-339) protein (GST tag)
CTSB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin B (CTSB) (AA 224-333) protein (GST tag)CTSB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin B (CTSB) (AA 21-339) protein (GST tag)CTSB 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Cathepsin B (CTSB) protein (His tag)CTSB 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Cathepsin B (CTSB) (Active) protein (His tag)CTSB 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Cathepsin B (CTSB) protein (His tag)CTSB 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE
Cathepsin B (CTSB) (AA 80-126) protein (His tag)Crystallography grade CTSB 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin B (CTSB) (AA 80-126) protein (His tag)Crystallography grade CTSB 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin B (CTSB) (AA 129-333) protein (His tag)Crystallography grade CTSB 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Cathepsin B (CTSB) (AA 80-333) protein (His tag)Crystallography grade CTSB 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 缓冲液
- 50 mM Tris, 150 mM NaCl, pH 8.0
- 注意事项
- Please avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
-
-
: "Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses." in: ACS infectious diseases, Vol. 4, Issue 8, pp. 1235-1245, (2018) (PubMed).
: "Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting." in: Scientific reports, Vol. 5, pp. 13476, (2015) (PubMed).
-
: "Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses." in: ACS infectious diseases, Vol. 4, Issue 8, pp. 1235-1245, (2018) (PubMed).
-
- 抗原
- Cathepsin B (CTSB)
- 别名
- Cathepsin B (CTSB 产品)
- 别名
- APPS Protein, CPSB Protein, CB Protein, apps Protein, cpsb Protein, LOC692390 Protein, CTSB Protein, cathepsin B Protein, cathepsin B S homeolog Protein, CTSB Protein, Ctsb Protein, ctsb.S Protein, LOC692390 Protein
- 背景
- Cathepsin B (CTSB) is also known as APP secretase (APPS) and CPSB, is an enzymatic protein belonging to the peptidase C1 family. Cathepsin B / CTSB is synthesized as a preproenzyme. Following removal of the signal peptide, the inactive proenzyme undergoes further modifications including removal of the pro region to result in the active enzyme. The catalytic activity of Cathepsin B / APPS contains: Hydrolysis of proteins with broad specificity for peptide bonds, Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L), In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. As a thiol protease, cathepsin B / CPSB is believed to participate in intracellular degradation and turnover of proteins and has also been implicated in tumor invasion and metastasis. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors.
- 分子量
- 36.7 kDa & 29.5 kDa
- NCBI登录号
- NP_001899
- 途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
-
