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Cathepsin B 产品

(Cathepsin B (CTSB))

Categories

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured Cathepsin B Categories

Cathepsin B 抗体

High quality antibodies with extensive validation data.

Cathepsin B ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Cathepsin B 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Cathepsin B 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (8)
Cat. No. ABIN3021176
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS, ICC, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (4)
Cat. No. ABIN687412
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (5)
Cat. No. ABIN7146996
Quantity 100 μg
Datasheet Datasheet

Recommended Cathepsin B ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6962721
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6974773
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954447
Quantity 96 tests
Datasheet Datasheet

Recommended Cathepsin B 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1350702
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN2752768
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1350704
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Cathepsin B Products

Karci, Canturk, Tarkun, Cetinarslan: "Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients." in: Endocrine, Vol. 57, Issue 1, pp. 148-155, (2018) (PubMed).

Hartmann, Lopez Cruz, Alameh, Ho, Rabideau, Pentelute, Bradley, Martchenko: "Characterization of Novel Piperidine-Based Inhibitor of Cathepsin B-Dependent Bacterial Toxins and Viruses." in: ACS infectious diseases, Vol. 4, Issue 8, pp. 1235-1245, (2018) (PubMed).

Zheng, Li, Wang, Wang, Liao, Hu, Fan, Kang, Zeng, Wu, Wu, Zhang, Wang, He et al.: "Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage ..." in: Autophagy, Vol. 12, Issue 9, pp. 1593-613, (2017) (PubMed).

Peng, Zhang, Zheng, Liang, Li, Chen, Guo, Yoshina, Chen, Zhao, Wu, Liu, Mitani, Yu, Xue: "Cysteine protease cathepsin B mediates radiation-induced bystander effects." in: Nature, Vol. 547, Issue 7664, pp. 458-462, (2017) (PubMed).

Jiang, Woosley, Sivalingam, Natarajan, Howe: "Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy." in: Nature cell biology, Vol. 18, Issue 8, pp. 851-63, (2016) (PubMed).

Liu, Xu, Ye, Liang, Wu, Zheng, Deng, Li, Liu: "Urinary proteins induce lysosomal membrane permeabilization and lysosomal dysfunction in renal tubular epithelial cells." in: American journal of physiology. Renal physiology, Vol. 308, Issue 6, pp. F639-49, (2015) (PubMed).

Gogiel, Wola?ska, Galewska, Kinalski, Sobolewski, Romanowicz: "Cathepsin B in human myometrium and in uterine leiomyomas at various stages of tumour growth." in: European journal of obstetrics, gynecology, and reproductive biology, Vol. 185, pp. 140-4, (2015) (PubMed).

Zilbermintz, Leonardi, Jeong, Sjodt, McComb, Ho, Retterer, Gharaibeh, Zamani, Soloveva, Bavari, Levitin, West, Bradley, Clubb, Cohen, Gupta, Martchenko: "Identification of agents effective against multiple toxins and viruses by host-oriented cell targeting." in: Scientific reports, Vol. 5, pp. 13476, (2015) (PubMed).

Liu, Tang, Zhang, Li, Yuan, Wang: "Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats." in: Neural regeneration research, Vol. 9, Issue 13, pp. 1288-96, (2014) (PubMed).

Balce, Allan, McKenna, Yates: "?-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages." in: The Journal of biological chemistry, Vol. 289, Issue 46, pp. 31891-904, (2014) (PubMed).

Synonyms and alternative names related to Cathepsin B

cathepsin B (CTSB), cathepsin B (Ctsb), cathepsin B S homeolog (ctsb.S), cathepsin B (LOC692390), APPS, apps, CB, CPSB, cpsb, CTSB, LOC692390

Protein level used designations for Cathepsin B

  • APP secretase
  • amyloid precursor protein secretase
  • cathepsin B1
  • cysteine protease
  • RSG-2
  • BCSB
  • cathepsin B
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