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M-CSF/CSF1 Protein (AA 33-190, Isoform 3)

Name: M-CSF/CSF1 Protein (AA 33-190, Isoform 3)
Brand: antibodies-online
SKU: ABIN2018212
Availability: OutOfStock

CSF1 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as analyzed by non-reducing SDS-PAGE. Active

2 μg of M-CSF, Human was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie Blue staining. (M-CSF/CSF1 Protein (AA 33-190, Isoform 3))

SDS

M-CSF, Human stimulates cell proliferation of M-NFS-60 cells. (M-CSF/CSF1 Protein (AA 33-190, Isoform 3))

AcA

2 images

(1 reference)

产品编号 ABIN2018212

发货至: 中国

Datasheet as PDF

抗原 See all M-CSF/CSF1 (CSF1) 蛋白

M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

蛋白类型

Recombinant

生物活性

Active

产品特性

Isoform 3, AA 33-190
宿主
35

20

6

1
人
资源
21

14

9

7

3

3

2

1

1

1
大肠杆菌（E. Coli）

产品特性

ED50 of 1 - 3 ng/mL, measured by cell proliferation assay of M-NFS-60, corresponding to a specific activity of 3.3 x 105-1 x 10^6 units/mg.
AA 33-190 (Isoform 3), expressed with an N-terminal Met.

纯度

> 95 % as analyzed by non-reducing SDS-PAGE.

内毒素水平

< 1 EU/μg, determined by LAL method.

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限制

仅限研究用
状态

Lyophilized

溶解方式

Reconstituted in ddH2O or PBS or Tris-HCl, pH 8.0 at 100 μg/mL.

缓冲液

Lyophilized after extensive dialysis against 50 mM Tris-HCl, pH 8.0.

储存条件

-80 °C

储存方法

Lyophilized recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhM-CSF should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

有效期

6 months
Bertin, Barat, Bélanger, Tremblay: "Leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells." in: Journal of neuroinflammation, Vol. 9, pp. 55, (2012) (PubMed).
抗原

M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

别名

Macrophage Colony Stimulating Factor (M-CSF) (CSF1 产品)

别名

CSF-1 Protein, MCSF Protein, C87615 Protein, Csfm Protein, op Protein, csf1-1 Protein, zgc:172186 Protein, CSF1 Protein, csf1-2 Protein, zgc:158436 Protein, colony stimulating factor 1 Protein, colony stimulating factor 1 (macrophage) Protein, colony stimulating factor 1a (macrophage) Protein, macrophage colony-stimulating factor 1 Protein, macrophage colony stimulating factor Protein, colony stimulating factor 1b (macrophage) Protein, CSF1 Protein, Csf1 Protein, csf1a Protein, LOC396599 Protein, LOC100860895 Protein, csf1b Protein

背景

Macrophage Colony-Stimulating Factor 1 (M-CSF), involved especially in monocytopoiesis,[1]is a hematopoietic growth factor. In mammals, it exits three isoforms, which invariably share an N-terminal 32-aa signal peptide, a 149-residue growth factor domain, a 21-residue transmembrane region and a 37-aa cytoplasmictail[2]. The biological activity of human M-CSF is maintained within the 149-aa growth factor domain[3], and it is only active in the disulfide-linked dimeric form[4], which is bonded at Cys63. Recombinant human Macrophage Colony-Stimulating Factor 1 (rhM-CSF) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 159 amino acids each. A fully biologically active molecule, rhM-CSF has a molecular mass of 28 kDaanalyzed by non-reducing SDS-PAGE and is obtained by proprietary refolding and chromatographic techniques.
Synonyms: Macrophage Colony Stimulating Factor, CSF-1, Lanimostim, MCSF, MGC31930, M-CSF.

分子量

28 kDa, observed by non-reducing SDS-PAGE.

UniProt

P09603

途径

RTK signaling