HVEM Protein (AA 39-184, AA 102-300) (Fc Tag)
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- 抗原 See all HVEM (TNFRSF14) 蛋白
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 39-184, AA 102-300
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宿主
- 人
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资源
- Insect cells (Sf9)
- 标记
- This HVEM protein is labelled with Fc Tag.
- 产品特性
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ED50 < 0.1 μg/mL, measured by the neutralization assay using 929 cells in presence of 0.25 ng/mL of human TNF-beta, corresponding to a specific activity of > 1x10^4 units/mg.
AA 39-184, fused with a C-terminal human Fc region AA 102-300 - 纯度
- > 95 % by SDS-PAGE and HPLC analyses.
- 内毒素水平
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product TNFRSF14 蛋白
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Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) protein (His tag)
TNFRSF14 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) protein (Fc Tag)TNFRSF14 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) (Active) protein (His tag)TNFRSF14 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Func Active
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 38-200) protein (His-DYKDDDDK-Strep II Tag)TNFRSF14 宿主: 人 宿主: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 39-202) (Active) protein (Fc Tag)TNFRSF14 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (Active) protein (Fc Tag)TNFRSF14 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE Active
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) protein (Fc Tag)TNFRSF14 宿主: 猕猴 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) protein (His tag)TNFRSF14 宿主: 猕猴 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (AA 38-283) protein (GST tag)TNFRSF14 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (Active) protein (His tag,Fc Tag)TNFRSF14 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstituted in ddH2
- 缓冲液
- Lyophilized after extensive dialysis against PBS.
- 储存条件
- -20 °C
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- 抗原
- HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))
- 别名
- HVEM (TNFRSF14 产品)
- 别名
- ATAR Protein, CD270 Protein, HVEA Protein, HVEM Protein, LIGHTR Protein, TR2 Protein, Atar Protein, HveA Protein, Hvem Protein, Tnfrs14 Protein, TNF receptor superfamily member 14 Protein, tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Protein, Tnfrsf14 Protein, TNFRSF14 Protein
- 物质类
- Viral Protein
- 背景
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Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3 Molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-gamma and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA),which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.Recombinant human HVEM-Fc (rhHVEM-Fc) produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhHVEM-Fc has a molecular mass of around 45 kDa analyzed by reducing SDS-PAGE.
Synonyms: TNFRSF14, TR2 - 分子量
- 45 kDa, observed by reducing SDS-PAGE.
- UniProt
- Q92956, P01857
- 途径
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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