Epigen Protein (AA 24-95)
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- 抗原 See all Epigen (EPGN) 蛋白
- Epigen (EPGN) (Epithelial Mitogen (EPGN))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- AA 24-95
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 产品特性
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ED50 < 1 xg/mL, measured by a cell proliferation assay using 3T3 cells, corresponding to a specific activity of > 1x 10^3 units/mg.
AA 24-95, expressed with an N-terminal Met. - 纯度
- > 95 % by SDS-PAGE analysis.
- 内毒素水平
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product EPGN 蛋白
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Epithelial Mitogen (EPGN) (AA 24-95) protein (His tag)
EPGN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Epithelial Mitogen (EPGN) (AA 1-133) protein (GST tag)EPGN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Epithelial Mitogen (EPGN) (AA 23-154) protein (rho-1D4 tag)Crystallography grade EPGN 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Epithelial Mitogen (EPGN) (AA 19-152) protein (rho-1D4 tag)Crystallography grade EPGN 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Epithelial Mitogen (EPGN) (AA 23-110) protein (His tag)EPGN 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 90 % by SDS - PAGE SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstituted in ddH2O at 100 μg/mL.
- 缓冲液
- Lyophilized after extensive dialysis against PBS.
- 储存条件
- -80 °C
- 储存方法
- Lyophilized recombinant human Epigen (rhEpigen) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhEpigen remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- 有效期
- 6 months
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- 抗原
- Epigen (EPGN) (Epithelial Mitogen (EPGN))
- 别名
- Epigen (EPGN 产品)
- 别名
- ALGV3072 Protein, EPG Protein, PRO9904 Protein, 2310069M11Rik Protein, epigen Protein, RGD1560084 Protein, epithelial mitogen Protein, EPGN Protein, Epgn Protein
- 背景
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Epigen is a cytokine belonging to the Epidermal Growth Factor (EGF) superfamily, which also includes Epiregulin, Amphiregulin, Neuregulin 2-beta, and Transforming Growth Factor alpha. The precursor of Epigen produced in tissues has 154 amino acids, and shares the characteristics of other members of EGF superfamily, including 3 disulfide bonds formed by 6 cysteines. Epigen is present in testis, heart, and liver, and it binds to EGF receptors with a much lower binding affinity than EGF. However, Epigen is more mitogenic than EGF. Epigen achieves its strong mitogenic potency by suppressing ligand-induced receptor inactivation. Unlike EGF, Epigen can also bind to EGF receptors in low pH conditions, helping its recycling. Therefore Epigen has anomalous potency due to its prolonged presence.Recombinant human Epigen (rhEpigen) produced in E. coli is a single non-glycosylated polypeptide chain containing 73 amino acids. A fully biologically active molecule, rhEpigen has a molecular mass of 8.1 kDa analyzed by reducing SDS-PAGE.
Synonyms: EPG, Epithelial mitogen - 分子量
- 8.1 kDa, observed by reducing SDS-PAGE.
- 途径
- RTK signaling, EGFR Signaling Pathway
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