STAT5B Protein (AA 1-321) (His tag)
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- 抗原 See all STAT5B 蛋白
- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1-321
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This STAT5B protein is labelled with His tag.
- 原理
- Recombinant Human Signal Transducer and Activator of Transcription 5B/STAT5B (C-6His)
- 序列
- MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC QQLPIPGPVE EMLAEVNATI TLEHHHHHH
- 产品特性
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Recombinant Human Signal Transducer and Activator of Transcription 5B/STAT5B (C-6His)
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product STAT5B 蛋白
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Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-321) protein (His tag)
STAT5B 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-390) protein (GST tag)STAT5B 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 678-787) protein (GST tag)STAT5B 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Signal Transducer and Activator of Transcription 5B (STAT5B) protein (Myc-DYKDDDDK Tag)STAT5B 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Supplied as a 0.2 μm filtered solution of PBS, 50 % Glycerol, 1 mM DTT, pH 7.4.
- 储存液
- Dithiothreitol (DTT)
- 注意事项
- This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- -80 °C
- 储存方法
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Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. - 有效期
- 6 months
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- 抗原
- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
- 别名
- Signal Transducer and Activator of Transcription 5B/STAT5B (STAT5B 产品)
- 别名
- STAT5 Protein, stat5 Protein, STAT5A Protein, STAT5B Protein, signal transducer and activator of transcription 5B Protein, signal transducer and activator of transcription 5B S homeolog Protein, Signal transducer and activator of transcription 5B Protein, STAT5B Protein, Stat5b Protein, stat5b.S Protein, LOC490969 Protein, sta5b Protein, LOC100566752 Protein, LOC100052954 Protein
- 背景
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Recombinant Human Signal Transducer and Activator of Transcription 5B/STAT5B is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Thr321) of Human STAT5B fused with a 6His tag at the C-terminus.
Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT5B mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6). STAT5 has two isoforms (A and B) that share 93 % AA identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival. - 分子量
- 38.4 kDa
- UniProt
- P51692
- 途径
- JAK/STAT Signaling, RTK signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
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