CCM2 Protein (His tag)
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- 抗原 See all CCM2 蛋白
- CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This CCM2 protein is labelled with His tag.
- 序列
- MGSSHHHHHHSSGLVPRGSHMEEEGKKGKKPGIVSPFKRV FLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLS DYIEKEVKYLGQLTSIPGYLNPSSRTEILHFIDNAKRAHQ LPGHLTQEHDAVLSLSAYNVKLAWRDGEDIILRVPIHDIA AVSYVRDDAAHLVVLKTAQDPGISPSQSLCAESSRGLSAG SLSESAVGPVEACCLVILAAESKVAAEELCCLLGQVFQVV YTESTIDFLDRAIFDGASTPTHHLSLHSDDSSTKVDIKET YEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQ DYMLTLRTKLSSQEIQQFAALLHEYRNGASIHEFCINLRQ LYGDSRKFLLLGLRPFIPEKDSQHFENFLETIGVKDGRGI ITDSFGRHRRALSTTSSSTTNGNRATGSSDDRSAPSEGDE WDRMISDISSDIEALGCSMDQDSA
- 产品特性
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Length (AA): 464
Chromosomal location: 7p13 - 纯度
- > 95 % by SDS-PAGE. Visualized by silver stain
- Top Product
- Discover our top product CCM2 蛋白
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Cerebral Cavernous Malformation 2 (CCM2) (AA 66-353) protein (His tag)
CCM2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Cerebral Cavernous Malformation 2 (CCM2) (AA 1-444) protein (GST tag)CCM2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Cerebral Cavernous Malformation 2 (CCM2) (AA 2-100) protein (GST tag)CCM2 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AA, AP
Cerebral Cavernous Malformation 2 (CCM2) (AA 1-444) protein (Strep Tag)Crystallography grade CCM2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Cerebral Cavernous Malformation 2 (CCM2) (AA 1-453) protein (Strep Tag)Crystallography grade CCM2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, SDS
Cerebral Cavernous Malformation 2 (CCM2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)CCM2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 应用备注
- Not tested so far.
- 说明
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Cytokines & Growth Factors
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- The lyophilized CCM-2 is soluble in water and most aqueous buffers and should be reconstituted in water or PBS.
- 缓冲液
- PBS
- 储存条件
- 0 °C
- 储存方法
- The lyophilized human CCM2, though stable at room temperature, is best stored desiccated below 0 °C.
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- 抗原
- CCM2 (Cerebral Cavernous Malformation 2 (CCM2))
- 别名
- CCM-2 (CCM2 产品)
- 别名
- C7orf22 Protein, OSM Protein, malcavernin Protein, CCM2 Protein, BC029157 Protein, TUF2 Protein, vtn Protein, zgc:110233 Protein, CCM2 scaffolding protein Protein, cerebral cavernous malformation 2 Protein, malcavernin Protein, CCM2 Protein, Ccm2 Protein, LOC100304744 Protein, ccm2 Protein
- 背景
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Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2). The roles of the CCM proteins in the pathogenesis of the disorder remain largely unknown. It was shown that the CCM1 gene product, KRIT1, interacts with the CCM2 gene product, malcavernin. Analogous to the established interactions of CCM1 and beta1 integrin with ICAP1, the CCM1/CCM2 association is dependent upon the phosphotyrosine binding (PTB) domain of CCM2. A familial CCM2 missense mutation abrogates the CCM1/CCM2 interaction, suggesting that loss of this interaction may be critical in CCM pathogenesis. CCM2 and ICAP1 bound to CCM1 via their respective PTB domains differentially influence the subcellular localization of CCM1. The data indicate that the genetic heterogeneity observed in familial CCM may reflect mutation of different molecular members of a coordinated signaling complex. The CCM-2 is fused to a N-terminal His-tag (6x His).
Synonyms: CCM-2, malcavernin, cerebral cavernous malformation 2, OSM, C7orf22, PP10187 - 分子量
- 51.0 kDa
- NCBI登录号
- NP_001025006, NM_001029835
- UniProt
- Q9BSQ5
- 途径
- Cell-Cell Junction Organization
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