CCM2 蛋白
(Cerebral Cavernous Malformation 2 (CCM2))
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].
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custom-made
CCM2
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
CCM2
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Aliases for CCM2 蛋白
CCM2 scaffolding protein (CCM2) 蛋白CCM2 scaffolding protein (Ccm2) 蛋白
cerebral cavernous malformation 2 (Ccm2) 蛋白
malcavernin (LOC100304744) 蛋白
cerebral cavernous malformation 2 (ccm2) 蛋白
BC029157 蛋白
C7orf22 蛋白
CCM2 蛋白
malcavernin 蛋白
OSM 蛋白
TUF2 蛋白
vtn 蛋白
zgc:110233 蛋白
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