SERPING1 Protein (AA 23-500) (His tag)
SERPING1
宿主: 人
宿主: 人细胞
Recombinant
> 95 % as determined by reducing SDS-PAGE.
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- 抗原 See all SERPING1 蛋白
- SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 23-500
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宿主
- 人
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资源
- 人细胞
- 标记
- This SERPING1 protein is labelled with His tag.
- 原理
- Recombinant Human Serpin G1/C1 Inhibitor (C-6His)
- 序列
- NPNATSSSSQ DPESLQDRGE GKVATTVISK MLFVEPILEV SSLPTTNSTT NSATKITANT TDEPTTQPTT EPTTQPTIQP TQPTTQLPTD SPTQPTTGSF CPGPVTLCSD LESHSTEAVL GDALVDFSLK LYHAFSAMKK VETNMAFSPF SIASLLTQVL LGAGENTKTN LESILSYPKD FTCVHQALKG FTTKGVTSVS QIFHSPDLAI RDTFVNASRT LYSSSPRVLS NNSDANLELI NTWVAKNTNN KISRLLDSLP SDTRLVLLNA IYLSAKWKTT FDPKKTRMEP FHFKNSVIKV PMMNSKKYPV AHFIDQTLKA KVGQLQLSHN LSLVILVPQN LKHRLEDMEQ ALSPSVFKAI MEKLEMSKFQ PTLLTLPRIK VTTSQDMLSI MEKLEFFDFS YDLNLCGLTE DPDLQVSAMQ HQTVLELTET GVEAAAASAI SVARTLLVFE VQQPFLFMLW DQQHKFPVFM GRVYDPRAVD HHHHHH
- 产品特性
- Recombinant Human Serpin G1 produced by transfected human cells is a secreted protein with sequence (Asn23-Ala500) of Human SERPING1 fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product SERPING1 蛋白
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Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1) (AA 1-500) protein (GST tag)
SERPING1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1) protein (His tag)SERPING1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1) proteinSERPING1 宿主: 人 宿主: Human Native >95 %
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM TrisHCl, 150 mM NaCl, pH 8.0.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- 4 °C/-20 °C/-80 °C
- 储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - 有效期
- 3 months
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- 抗原
- SERPING1 (Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1 (SERPING1))
- 别名
- c1-inhibitor (SERPING1 产品)
- 别名
- fb64f02 Protein, im:7159527 Protein, si:dkeyp-110g5.2 Protein, wu:fb60c09 Protein, wu:fb62a08 Protein, wu:fb64f02 Protein, LOC100136072 Protein, C1-INH Protein, C1INH Protein, C1nh Protein, C1IN Protein, C1NH Protein, HAE1 Protein, HAE2 Protein, serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Protein, C1 inhibitor Protein, serpin family G member 1 Protein, serine (or cysteine) peptidase inhibitor, clade G, member 1 Protein, serping1 Protein, LOC100136072 Protein, SERPING1 Protein, Serping1 Protein
- Sub Type
- Fusionprotein
- 背景
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The Human Serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis. Serpin G1 is a serine protease inhibitor protein. Serpin G1 is the largest member among the serpin class of proteins. Remarkably, Serpin G1 has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of Serpin G1 provides the inhibitory activity. The N-terminal domain is not essential for Serpin G1 to inhibit proteinases and has no similarity to other proteins. The main function of Serpin G1 is the inhibition of the complement system to prevent spontaneous activation. Serpin G1 is an acute phase protein and circulates in blood at levels of around 0.25g/L, whose levels rise 2-fold during inflammation. Although named after its complement inhibitory activity, Serpin G1 also inhibits proteinases of the fibrinolytic, clotting, and kinin pathways. Most notably, Serpin G1 play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. It is also the most important physiological inhibitor of fXIIa, chymotrypsin and plasma kallikrein.
Alternative Names: Plasma Protease C1 Inhibitor, C1 Inh, C1Inh, C1 Esterase Inhibitor, C1-Inhibiting Factor, Serpin G1, SERPING1, C1IN, C1NH - 分子量
- 53.9 kDa
- UniProt
- P05155
- 途径
- Complement System
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