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SERPINA7 Protein (AA 21-415) (His tag)

SERPINA7 宿主: 人 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
产品编号 ABIN1097517
发货至: 中国
  • 抗原 See all SERPINA7 蛋白
    SERPINA7 (Serpin Family A Member 7 (SERPINA7))
    蛋白类型
    Recombinant
    产品特性
    AA 21-415
    宿主
    • 5
    • 4
    • 3
    • 1
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    • 1
    • 1
    资源
    • 6
    • 5
    • 2
    • 1
    • 1
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    人细胞
    标记
    This SERPINA7 protein is labelled with His tag.
    原理
    Recombinant Human Serpin A7/TBG (C-6His)
    序列
    ASPEGKVTAC HSSQPNATLY KMSSINADFA FNLYRRFTVE TPDKNIFFSP VSISAALVML SFGACCSTQT EIVETLGFNL TDTPMVEIQH GFQHLICSLN FPKKELELQI GNALFIGKHL KPLAKFLNDV KTLYETEVFS TDFSNISAAK QEINSHVEMQ TKGKVVGLIQ DLKPNTIMVL VNYIHFKAQW ANPFDPSKTE DSSSFLIDKT TTVQVPMMHQ MEQYYHLVDM ELNCTVLQMD YSKNALALFV LPKEGQMESV EAAMSSKTLK KWNRLLQKGW VDLFVPKFSI SATYDLGATL LKMGIQHAYS ENADFSGLTE DNGLKLSNAA HKAVLHIGEK GTEAAAVPEV ELSDQPENTF LHPIIQIDRS FMLLILERST RSILFLGKVV NPTEAVDHHH HHH
    产品特性
    Recombinant Human Serpin A7 produced by transfected human cells is a secreted protein with sequence (Ala21-Ala415) of human SERPIN A7 fused with a polyhistidine tag at the C-terminus.
    纯度
    > 95 % as determined by reducing SDS-PAGE.
    过滤
    0.2 μm filtered
    内毒素水平
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product SERPINA7 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    缓冲液
    Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 5 % Threhalose, pH 7.2.
    注意事项
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    储存条件
    4 °C/-20 °C/-80 °C
    储存方法
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at < -20°C for 3 months.
    有效期
    3 months
  • 抗原
    SERPINA7 (Serpin Family A Member 7 (SERPINA7))
    别名
    t4-binding-globulin (SERPINA7 产品)
    别名
    C730040N12Rik Protein, Tbg Protein, TBG Protein, THYROXINE-BINDING GLOBULIN Protein, serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 Protein, serpin family A member 7 Protein, Serpina7 Protein, SERPINA7 Protein
    Sub Type
    Fusionprotein
    背景
    Serpin A7 is a secreted protein which belongs to the Serpin family. As a 54 kDa protein, Serpin A7 is synthesized primarily in the liver and secreted in plasma. Genomically, Serpin A7 is a serpin, although it has no inhibitory function like many other members of this class of proteins. Serpin A7 binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3’-triiodothyronine (T3) in the bloodstream. Of these three proteins, Serpin A7 has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, Serpin A7 carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3 in the blood, Serpin A7 is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, Serpin A7 has a single binding site for T4/T3. Serpin A7 tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone, and defects in Serpin A7 are a cause of Serpin A7 deficiency.
    Alternative Names: Thyroxine-Binding Globulin, Serpin A7, T4-Binding Globulin, SERPINA7, TBG
    分子量
    45.14 kDa
    UniProt
    P05543
    途径
    Hormone Transport
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