CD46 Protein (CD46) (AA 35-328) (His tag)
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- 抗原 See all CD46 蛋白
- CD46
- 蛋白类型
- Recombinant
- 产品特性
- AA 35-328
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宿主
- 人
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资源
- 人细胞
- 标记
- This CD46 protein is labelled with His tag.
- 原理
- Recombinant Human CD46/MCP (C-6His)
- 序列
- CEEPPTFEAM ELIGKPKPYY EIGERVDYKC KKGYFYIPPL ATHTICDRNH TWLPVSDDAC YRETCPYIRD PLNGQAVPAN GTYEFGYQMH FICNEGYYLI GEEILYCELK GSVAIWSGKP PICEKVLCTP PPKIKNGKHT FSEVEVFEYL DAVTYSCDPA PGPDPFSLIG ESTIYCGDNS VWSRAAPECK VVKCRFPVVE NGKQISGFGK KFYYKATVMF ECDKGFYLDG SDTIVCDSNS TWDPPVPKCL KVSTSSTTKS PASSASGPRP TYKPPVSNYP GYPKPEEGIL DSLDLDHHHH HH
- 产品特性
- Recombinant Human CD46 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Cys35-Asp328) of Human CD46 fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
- Top Product
- Discover our top product CD46 蛋白
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CD46 (CD46) (AA 35-343) protein (His tag)
CD46 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD46 (CD46) (AA 35-329) protein (His tag)CD46 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD46 (CD46) (AA 45-344) protein (His tag)CD46 宿主: 犬 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
CD46 (CD46) (AA 35-313) protein (His tag)CD46 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
CD46 (CD46) (AA 1-384) protein (GST tag)CD46 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
CD46 (CD46) (AA 36-135) protein (GST tag)CD46 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
CD46 (CD46) (AA 45-329) protein (His tag)Crystallography grade CD46 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
CD46 (CD46) (AA 45-365) protein (rho-1D4 tag)Crystallography grade CD46 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
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It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. - 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
- 注意事项
- Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
- 储存条件
- 4 °C/-20 °C/-80 °C
- 储存方法
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Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. - 有效期
- 3 months
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- 抗原
- CD46
- 别名
- cd46 (CD46 产品)
- 别名
- AHUS2 Protein, MCP Protein, MIC10 Protein, TLX Protein, TRA2.10 Protein, Mcp Protein, CD46 Protein, CD46 molecule Protein, CD46 antigen, complement regulatory protein Protein, CD46 molecule, complement regulatory protein Protein, membrane cofactor protein-like Protein, CD46 Protein, Cd46 Protein, LOC100341359 Protein, LOC103789310 Protein
- Sub Type
- Fusionprotein
- 背景
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CD46 is a type I membrane protein containing four Sushi domains. CD46 is expressed by all cells except erythrocytes. CD46 has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. CD46 acts as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria.
Alternative Names: Membrane Cofactor Protein, TLX, Trophoblast Leukocyte Common Antigen, CD46, MCP, MIC10 - 分子量
- 33.83 kDa
- UniProt
- P15529
- 途径
- Regulation of Actin Filament Polymerization
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