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Human Monoclonal ING1 Primary Antibody for ICC, IF - ABIN2668666
Boland, Olineck, Bonnefin, Vieyra, Parr, Riabowol: A panel of CAb antibodies recognize endogenous and ectopically expressed ING1 protein. in Hybridoma 2000
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Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
ING1 regulates the nucleolar epigenome and rDNA transcription suggesting that regulation of protein synthesis might serve as the basis for ING1 function as a type II tumor suppressor.
ING1a acts as a novel link in the activation of the Rb pathway that can impose senescence in the absence of activating p53 (显示 TP53 抗体)-mediated DNA damage signaling, and should prove useful in defining the molecular events contributing to Rb-induced senescence.
These data indicate that stromal ING1 expression can predict the survival of patients with luminal breast cancer
Overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1.
Results show that ING1 expression is under-regulated in pancreatic duct adenocarcinoma (PDAC) and is a direct target of miR (显示 MLXIP 抗体)-371-5p involved in miR (显示 MLXIP 抗体)-371-5p inducing promotion of PDAC cells proliferation.
ING1b finely regulates the hypoxic response by triggering HIF1alpha (显示 HIF1A 抗体) proteasomal degradation.
ING1b sumoylation regulates the binding of ING1b to the ISG15 (显示 ISG15 抗体) and DGCR8 (显示 DGCR8 抗体) promoters, consequently regulating ISG15 (显示 ISG15 抗体) and DGCR8 (显示 DGCR8 抗体) transcription.
Our results identify a novel functional relationship between cytoplasmic p33ING1b and oral squamous cell carcinoma patient survival
ING1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 (显示 TP53 抗体) status.
Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
ING1b is an important regulator of osteoblast differentiation and suppresses PPAR-beta (显示 PPARD 抗体)/delta.
Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1.
Study reveals a novel connection between ING1 and a regulator of microRNA biogenesis and identifies new links between tumor suppressor proteins and the microRNA machinery.
Identification of the p33(ING1)-regulated genes that include cyclin B1 (显示 CCNB1 抗体) and proto-oncogene (显示 RAB1A 抗体) DEK (显示 DEK 抗体) by using cDNA microarray in a mouse mammary epithelial cell line NMuMG
Characterization of nuclear localization signal in mouse ING1 homolog protein.
p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras
the suggested role of ing1 as a candidate tumor suppressor gene involved in control of DNA damage response.
p37 (显示 UBXN2B 抗体)(Ing1) can negatively regulate cell growth and apoptosis in a p53 (显示 TP53 抗体)-independent manner.
important role for the Ing1 locus in protection against oncogenic stress in vivo, both as a mediator of p53 (显示 TP53 抗体) activation and as a regulator of chromatin remodeling processes.
This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.
inhibitor of growth family, member 1
, inhibitor of growth protein 1
, growth inhibitor ING1
, growth inhibitory protein ING1
, tumor suppressor ING1
, inhibitor of growth
, tumor suppressor