PRKAA2 产品
(Protein Kinase, AMP-Activated, alpha 2 Catalytic Subunit (PRKAA2))
Categories
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008].
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Featured PRKAA2 Categories
PRKAA2 抗体
High quality antibodies with extensive validation data.
PRKAA2 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PRKAA2 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRKAA2 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, RNAi, PLA
Validations
- (6)
Cat. No.
ABIN519168
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, IHC (p), IP, ICC
Validations
- (3)
- (5)
Cat. No.
ABIN2855639
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey
Application
WB, ELISA, IHC, FACS, ICC, Neut
Validations
- (7)
Cat. No.
ABIN5611223
Quantity
0.1 mg
Datasheet
Datasheet
Recommended PRKAA2 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969726
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1119510
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Validations
Cat. No.
ABIN1119511
Quantity
96 tests
Datasheet
Datasheet
Recommended PRKAA2 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Insect cells (Sf21)
Validations
- (2)
Cat. No.
ABIN5569698
Quantity
5 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7321284
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124658
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our PRKAA2 Products
: "Metformin protects against PM2.5-induced lung injury and cardiac dysfunction independent of AMP-activated protein kinase α2." in: Redox biology, Vol. 28, pp. 101345, (2020) (PubMed).: "The evidence of metabolic-improving effect of metformin in Ay/a mice with genetically-induced melanocortin obesity and the contribution of hypothalamic mechanisms to this effect." in: PLoS ONE, Vol. 14, Issue 3, pp. e0213779, (2019) (PubMed).
: "Alternative polyadenylation drives genome-to-phenome information detours in the AMPKα1 and AMPKα2 knockout mice." in: Scientific reports, Vol. 8, Issue 1, pp. 6462, (2018) (PubMed).
: "Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD‑induced obese mice." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 680-686, (2017) (PubMed).
: "LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress." in: Nature cell biology, Vol. 18, Issue 4, pp. 431-42, (2016) (PubMed).
: "AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration." in: The Journal of biological chemistry, Vol. 290, Issue 44, pp. 26445-56, (2015) (PubMed).
: "High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1)." in: The Journal of biological chemistry, Vol. 290, Issue 14, pp. 9183-94, (2015) (PubMed).
: "Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells." in: Breast cancer research : BCR, Vol. 16, Issue 4, pp. 420, (2015) (PubMed).
: "Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo." in: Nature medicine, Vol. 18, Issue 6, pp. 902-10, (2012) (PubMed).
: "Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK." in: Nature, Vol. 482, Issue 7384, pp. 251-5, (2012) (PubMed).
Synonyms and alternative names related to PRKAA2
protein kinase AMP-activated catalytic subunit alpha 2 (PRKAA2), protein kinase AMP-activated catalytic subunit alpha 2 (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit (Prkaa2), protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog (prkaa2.S), protein kinase, AMP-activated, alpha 2 catalytic subunit (prkaa2), 2310008I11Rik, A830082D05, AMPK, Ampk, ampk, AMPK2, ampk2, AMPKa2, Ampka2, AMPKA2, AMPKalpha2, PRKAA, prkaa, prkaa1, PRKAA2Protein level used designations for PRKAA2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2
- 5'-AMP-activated protein kinase, catalytic alpha-2 chain
- ACACA kinase
- AMPK subunit alpha-2
- AMPK-alpha-2 chain
- HMGCR kinase
- acetyl-CoA carboxylase kinase
- hydroxymethylglutaryl-CoA reductase kinase
- AMP-activated protein kinase
- AMPK alpha-2 chain
- AMP-activated protein kinase alpha-2 variant B
- AMP-activated protein kinase alpha 2
- protein kinase AMP-activated alpha 2 catalytic subunit
- SNF1-like protein AMPK
- 5'-AMP-activated protein kinase alpha-2 catalytic subunit
- AMPKalpha2
- ampka2
- AMP-activated protein kinase alpha 2 catalytic subunit
- protein kinase, AMP-activated, alpha 2 catalytic subunit
- AMPK-activated protein kinase alpha-2 subunit
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