PRKAB1 产品
(Protein Kinase, AMP-Activated, beta 1 Non-Catalytic Subunit (PRKAB1))
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The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008].
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Featured PRKAB1 Categories
PRKAB1 抗体
High quality antibodies with extensive validation data.
PRKAB1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PRKAB1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PRKAB1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7269654
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro)
Validations
- (4)
Cat. No.
ABIN683068
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (4)
Cat. No.
ABIN737901
Quantity
100 μL
Datasheet
Datasheet
Recommended PRKAB1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969728
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969727
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958933
Quantity
96 tests
Datasheet
Datasheet
Recommended PRKAB1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124659
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316211
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7280002
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PRKAB1 Products
: "Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells." in: Redox biology, Vol. 17, pp. 180-191, (2018) (PubMed).: "Reduced expression of AMPK-β1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer." in: Molecular cancer, Vol. 13, pp. 49, (2014) (PubMed).
: "The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor." in: The Journal of biological chemistry, Vol. 282, Issue 41, pp. 30107-19, (2007) (PubMed).
: "C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3817-27, (2004) (PubMed).
: "AMP-activated protein kinase plays a role in the control of food intake." in: The Journal of biological chemistry, Vol. 279, Issue 13, pp. 12005-8, (2004) (PubMed).
: "AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus." in: Nature, Vol. 428, Issue 6982, pp. 569-74, (2004) (PubMed).
: "Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit." in: The Journal of biological chemistry, Vol. 272, Issue 39, pp. 24475-9, (1997) (PubMed).
: "Phosphorylation of rat muscle acetyl-CoA carboxylase by AMP-activated protein kinase and protein kinase A." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 82, Issue 1, pp. 219-25, (1997) (PubMed).
: "Isoform-specific purification and substrate specificity of the 5'-AMP-activated protein kinase." in: The Journal of biological chemistry, Vol. 271, Issue 45, pp. 28445-50, (1996) (PubMed).
: "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro." in: The Journal of biological chemistry, Vol. 271, Issue 17, pp. 10282-90, (1996) (PubMed).
Synonyms and alternative names related to PRKAB1
protein kinase AMP-activated non-catalytic subunit beta 1 (PRKAB1), protein kinase, AMP-activated, beta 1 non-catalytic subunit (Prkab1), protein kinase AMP-activated non-catalytic subunit beta 1 (Prkab1), protein kinase, AMP-activated, beta 1 non-catalytic subunit S homeolog (prkab1.S), protein kinase, AMP-activated, beta 1 non-catalytic subunit (prkab1), protein kinase, AMP-activated, beta 1 non-catalytic subunit, b (prkab1b), protein kinase, AMP-activated, beta 1 non-catalytic subunit, a (prkab1a), 1300015D22Rik, AMPK, AU021155, E430008F22, HAMPKb, MGC82489, prkab1, wu:fk93d05, wu:fw87e09, zgc:56652, zgc:76975, zgc:92228Protein level used designations for PRKAB1
- 5'-AMP-activated protein kinase beta-1 subunit
- 5'-AMP-activated protein kinase subunit beta-1
- AMP-activated protein kinase beta subunit
- AMPK beta -1 chain
- AMPK beta 1
- AMPK subunit beta-1
- AMPKb
- protein kinase, AMP-activated, noncatalytic, beta-1
- 5'-AMP-activated protein kinase 40 kDa subunit
- 5'-AMP-activated protein kinase, beta subunit
- 5-AMP-activated protein kinase beta subunit
- AMPK beta-1 chain
- 5'AMP-activated protein kinase beta-1 non-catalytic subunit
- protein kinase, AMP-activated, beta 1 non-catalytic subunit
- AMP-activated protein kinase beta 1 non-catalytic subunit
- AMPK-activated protein kinase beta-1 subunit
- protein kinase, AMP-activated, beta 1 non-catalytic subunit, b
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