(Pleckstrin Homology Domain Interacting Protein (PHIP))
PHIP binds the pleckstrin homology (PH) domain of insulin receptor substrate-1 (IRS1\; MIM 147545), modulates insulin signaling, and plays a role in pancreatic beta cell growth and survival (Farhang-Fallah et al., 2000 [PubMed 11018022]\; Podcheko et al., 2007 [PubMed 17636024]).[supplied by OMIM, Jun 2009].
De Semir, Nosrati, Bezrookove, Dar, Federman, Bienvenu, Venna, Rangel, Climent, Meyer Tamgüney, Thummala, Tong, Leong, Haqq, Billings, Miller, Sagebiel, Debs, Kashani-Sabet: "Pleckstrin homology domain-interacting protein (PHIP) as a marker and mediator of melanoma metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 18, pp. 7067-72, (2012) (PubMed).