PHLPP2 抗体
(PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| PHLPP2 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (C-Term) | 人, 小鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (C-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 (C-Term) | 人 | 山羊 Polyclonal |
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| PHLPP2 抗体 (AA 4-31) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (C-Term) | 人, 小鼠, 豚鼠, 兔 | 兔 Polyclonal |
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| PHLPP2 抗体 (AA 1295-1323) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (C-Term) | 人, 小鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) | 人 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) (Biotin) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) (HRP) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) (APC) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| PHLPP2 抗体 (N-Term) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB15007
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 1295-1323, C-Term
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB15006
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 4-31, N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 4-31
Primary Antibody
- WB (Western Blotting: 所列应用)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人, 小鼠, 豚鼠, 兔
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- FACS (Flow Cytometry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 1295-1323
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- IF (Immunofluorescence: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IP (Immunoprecipitation: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- EIA (Enzyme Immunoassay: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- C-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- Biotin
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- HRP
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- 质量等级
- Carrier-free
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- APC
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Latest Publications for our PHLPP2 抗体
: "Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection." in: Mitochondrion, Vol. 13, Issue 6, pp. 566-76, (2013) (PubMed).
: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).
: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).
: "Biomarkers of response to Akt inhibitor MK-2206 in breast cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 20, pp. 5816-28, (2012) (PubMed).
: "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth." in: Molecular cell, Vol. 18, Issue 1, pp. 13-24, (2005) (PubMed).
Aliases for PHLPP2 抗体
PH domain and leucine rich repeat protein phosphatase 2 (PHLPP2) 抗体PH domain and leucine rich repeat protein phosphatase 2 S homeolog (phlpp2.S) 抗体
PH domain and leucine rich repeat protein phosphatase 2 (phlpp2) 抗体
PH domain and leucine rich repeat protein phosphatase 2 (Phlpp2) 抗体
AI481772 抗体
C130044A18Rik 抗体
PHLPPL 抗体
phlppl 抗体
Phlppl 抗体
RGD1562857 抗体
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