anti-马 Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) 抗体 for Western Blotting

Recommended Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Antibody (supplied by: Log in to see )

抗原
Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) 抗体
  • GR
  • gcr
  • grl
  • xGR
  • gccr
  • gr
  • zgc:113038
  • NR3C1
  • GCL
  • LOC100302444
  • Gcr
  • Grl
  • Grl-1
  • Grl1
  • GRL
  • GCCR
  • GCR
  • NO
  • GR-A
  • nr3c1
  • nuclear receptor subfamily 3 group C member 1
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • nuclear receptor subfamily 3, group C, member 1
  • glucocorticoid receptor
  • NR3C1
  • nr3c1
  • LOC100302444
  • Nr3c1
抗原表位
N-Term
25
25
21
18
18
16
14
11
10
10
7
7
7
6
5
5
5
5
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
适用
牛, 豚鼠, 马, 人, 小鼠, 猪, 大鼠
301
156
137
22
21
17
15
8
5
4
3
2
1
1
1
1
1
宿主

241
78
5
克隆类型
多克隆
标记
非结合性
20
20
10
8
7
6
4
4
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
253
142
109
82
74
53
46
39
35
18
6
5
4
3
2
2
2
选项
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产品编号 ABIN2782262
$ 289.00
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
7.7976923 ABIN2777208 IHC WB Rabbit N-Term Log in to see Polyclonal 0
1 ABIN1918434 IF IHC IHC (p) IP WB Rabbit IgG AA 150-200 Log in to see Polyclonal 0

General

抗原 Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) 抗体
抗原表位 N-Term
(25), (25), (21), (18), (18), (16), (14), (11), (10), (10), (7), (7), (7), (6), (5), (5), (5), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
适用 牛, 豚鼠, 马, 人, 小鼠, 猪, 大鼠
(301), (156), (137), (22), (21), (17), (15), (8), (5), (4), (3), (2), (1), (1), (1), (1), (1)
宿主
(241), (78), (5)
克隆类型
多克隆
标记 非结合性
(20), (20), (10), (8), (7), (6), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
应用范围 Immunohistochemistry (IHC), Western Blotting (WB)
(253), (142), (109), (82), (74), (53), (46), (39), (35), (18), (6), (5), (4), (3), (2), (2), (2)
Pubmed 找到1个引用
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产品细节

目标详细情况 使用细节 贮存及处理 引用 图像
Blocking Peptide Blocking peptide for this product available: ABIN980920
序列 NVKLYTTDQS TFDILQDLEF SSGSPGKETN ESPWRSDLLI DENCLLSPLA
预测反应 Cow: 100%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%
产品特性 This is a rabbit polyclonal antibody against NR3C1. It was validated on Western Blot using a cell lysate as a positive control.
纯化方法 Affinity Purified
免疫原 The immunogen is a synthetic peptide directed towards the N terminal region of human NR3C1

目标详细情况

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抗原
别名 NR3C1 (NR3C1 Antibody 摘要)
背景 NR3C1 is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined.
Alias Symbols: GCCR, GCR, GR, GRL
Protein Interaction Partner: TTC5, HSP90AA1, TXN2, UBC, TXN, FKBP5, DCAF6, RABEP2, BRCC3, LARP7, GAPVD1, CD2AP, SF3A1, HNRNPR, TRIM28, HDAC1, MTA2, CCDC6, CENPB, TMF1, PPARG, STUB1, BAG1, RPS6KA5, NCOA1, POLR1D, NCOA2, SRA1, PRKDC, RAD54L2, MAGEA11, PPP5C, PPID, GNB2, GNB1, FKBP4, GN
Protein Size: 777
分子量 86 kDa
基因ID 2908
NCBI登录号 NM_000176, NP_000167
UniProt P04150
途径 Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Regulation of Carbohydrate Metabolic Process

使用细节

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应用备注 Optimal working dilutions should be determined experimentally by the investigator.
说明

Antigen size: 777 AA

限制 仅限研究用

贮存及处理

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状态 Liquid
浓度 Lot specific
缓冲液 Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项 Avoid repeated freeze-thaw cycles.
储存条件 -20 °C
储存方法 For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

引用

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背景

Yoshikawa, Shimizu, Sano, Ohnuma, Iwata, Hosono, Fukuda, Morimoto, Tanaka: "Role of the hinge region of glucocorticoid receptor for HEXIM1-mediated transcriptional repression." in: Biochemical and biophysical research communications, Vol. 371, Issue 1, pp. 44-9, 2008

图像

产品细节 目标详细情况 使用细节 贮存及处理 引用 回页首
厂商提供的图像
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (N-Term) antibody (ABIN2782262) WB Suggested Anti-NR3C1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Posi...
Immunohistochemistry (IHC) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (N-Term) antibody (ABIN2782262) Immunohistochemistry with Colon, submucosal plexus tissue at an antibody concentratio...
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) (N-Term) antibody (ABIN2782262) Host: Rabbit Target Name: NR3C1 Sample Type: Hela Antibody Dilution: 1.0ug/ml