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|抗原||Sequestosome 1 (SQSTM1) 抗体|
|抗原表位||AA 80-130 其他选择|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This SQSTM1 antibody is un-conjugated 其他选择|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
SQSTM1抗体详情SQSTM1目标详情 使用细节 贮存及处理 References for anti-SQSTM1 antibody (ABIN682153) 图像
|纯化方法||Purified by Protein A.|
|免疫原||KLH conjugated synthetic peptide derived from human SQSTM1/Ubiquitin-binding protein p62|
|Plasmids, Primers & others|
SQSTM1目标详情SQSTM1抗体详情 使用细节 贮存及处理 References for anti-SQSTM1 antibody (ABIN682153) 图像 回页首
|别名||Sqstm1 (SQSTM1 Antibody 摘要)|
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Subcellular location: Cytoplasm, Nucleus
Synonyms: p60, p62, A170, OSIL, PDB3, ZIP3, p62B, Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62, SQSTM1, ORCA
|途径||NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy|
使用细节SQSTM1抗体详情 SQSTM1目标详情 贮存及处理 References for anti-SQSTM1 antibody (ABIN682153) 图像 回页首
贮存及处理SQSTM1抗体详情 SQSTM1目标详情 使用细节 References for anti-SQSTM1 antibody (ABIN682153) 图像 回页首
|缓冲液||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|注意事项||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|储存方法||Store at -20°C|
References for anti-SQSTM1 antibody (ABIN682153)SQSTM1抗体详情 SQSTM1目标详情 使用细节 贮存及处理 图像 回页首
Kuo, Weng, Chang, Huang, Lin, Chuang, Lin, Liou, Tai, Lin, Wang: "Altered mitochondrial dynamics and response to insulin in cybrid cells harboring a diabetes-susceptible mitochondrial DNA haplogroup." in: Free radical biology & medicine, Vol. 96, pp. 116-29, 2016 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Xia, Gao, Zhang, Wang, Zhao, Che, Ao, Yang, Wang, Lei: "Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-γ-induced malignant transformation of primary bovine mammary epithelial cells." in: Cell death discovery, Vol. 2, pp. 15065, 2016 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Cow (Bovine)). Further details: Sample: mammary gland
Cui, Luo, Li, Li, Wang: "Changes of intracellular Ca2+ in quercetin-induced autophagy progression." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 11, pp. 908-14, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Human).
Chen, Wei, Nie, Lin, Tian, Liu, Yu, Cheng, Yan, Wang, Liu, Deng, Lai, Zhou, Zhang, Lin, Chen: "?-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in asenescence-accelerated prone 8 mice." in: Brain research, Vol. 1552, pp. 41-54, 2014 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)). Further details: Sample: brain
图像SQSTM1抗体详情 SQSTM1目标详情 使用细节 贮存及处理 References for anti-SQSTM1 antibody (ABIN682153) 回页首