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Mouse (Murine) IL1A Protein expressed in Escherichia coli (E. coli) - ABIN2007346
Dinarello: Biologic basis for interleukin-1 in disease. in Blood 1996
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These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr (显示 FSHR 蛋白) expression.
Following vasectomy, IL1alpha, IL1beta (显示 IL1B 蛋白), IL1ra (显示 IL1RN 蛋白), IL10 (显示 IL10 蛋白), and TNF-alpha (显示 TNF 蛋白) may mediate immune reaction in whole epididymis, whereas IL6 (显示 IL6 蛋白) and TGF-beta1 (显示 TGFB1 蛋白) may mediate regionally different immune response primarily in the lower part of epididymis.
Since neither IL-1alpha nor IL-1beta (显示 IL1B 蛋白) depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta (显示 IL1B 蛋白) have a similar and probably complementary role in FHF progression
These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion.
Our findings indicate that IL-1 plays an important role in skin lesions of systemic lupus erythematosus (SLE), suggesting that IL-1 is a therapeutic target in skin lesions of SLE.
our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE (显示 AGER 蛋白)-p38 MAPK (显示 MAPK14 蛋白) and calpain-1 (显示 CAPN1 蛋白) pathway in keratinocyte and this mechanism may play an important role during psoriasis.
IL-1 and IL-36 have roles as inflammatory mediators in pustular psoriasis in a mouse model
These data demonstrate that IL-1 functions as a mitogenic mediator of encephalitogenic Th17 cells rather than qualitative inducer of their generation
Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease.
endothelial cells were identified as the primary cellular source of G-CSF (显示 CSF3 蛋白) during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue.
Obesity was associated with higher expression of NILCO molecules (Notch (显示 NOTCH1 蛋白)-IL1-leptin (显示 LEP 蛋白)) in type II endometrial cancer.
through IL-1alpha production, airway epithelial cells induce a pro-inflammatory lung fibroblast phenotype that is further enhanced with cigarette smoke extract exposure in COPD (显示 ARCN1 蛋白), suggesting an aberrant epithelial-fibroblast interaction in COPD (显示 ARCN1 蛋白)
our study has described the association between rs3783550 (IL-1A), rs3783546 (IL-1A) and rs2853550 (IL-1B) and AS risk and between a new haplotype, "TCG", of rs3783550, rs3783546 and rs2853550 and AS in Chinese Han population.
In conclusion, the analyzed IL1A -889 C>T, IL1B (显示 IL1B 蛋白) +3954 C>T, and IL6 (显示 IL6 蛋白) -174 G>C polymorphisms may be associated with the occurrence and development of human cytomegalovirus infection among studied patients.
Lipid apheresis suppresses the expression of IL-1alpha, IL-6 (显示 IL6 蛋白) and TNF-alpha (显示 TNF 蛋白) mRNA in patients with dyslipidaemias.
results suggest a role for prostatic expression of TGF-B, IL-1a, TGFBRI and TGFBRII as prognostic markers for prostate cancer. The rational combination of novel agents directed toward the inactivation of TGF-B, IL-1a, TGFBRI and TGFBRII could disrupt complementary tumor cell proliferation pathways.
There were no significant differences in GE area of infertile and fertile women. C-C motif chemokine 11 (P=0.048), TGFalpha (P=0.049), IFNgamma (P=0.033) and interleukin-1 alpha (P=0.047) were significantly elevated in uterine lavage from infertile women <35years compared to fertile but not in women 35years
The authors' findings suggest that IL-1a rs3783553 polymorphism may modulate the risk of squamous cell carcinoma of the oropharynx recurrence in patients, particularly for patients with HPV16-positive tumors.
Based on current meta-analysis, we indicated that there is lack of association between the three SNPs of IL-1 and primary open-angle glaucoma.
results showed that IL-1A -889C/T (rs1800587) was associated with systemic sclerosis susceptibility in the Chinese population
Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.
Testicular IL-1 alpha and IL-1 beta (显示 IL1B 蛋白) concentrations were highest in the early post-natal period; however, IL-1 bioactivity and IL-6 (显示 IL6 蛋白) concentrations were greatest in the immediate pre-pubertal period.
Genes for IL-1alpha and IL-1beta (显示 IL1B 蛋白) are expressed and a functional IL-1R is present in bovine corpora lutea throughout luteal phase. IL-1alpha and IL-1beta (显示 IL1B 蛋白) may have different roles as regulating PGF (显示 PGF 蛋白)(2alpha) and PGE (显示 LIPF 蛋白)(2) production during luteal phase.
non-metalloproteinase mechanisms participate in IL-1-induced matrix degradation and loss of tissue material properties
These results suggest that IL-1alpha and IL-1beta (显示 IL1B 蛋白) are produced by the stromal cells, that IL-1beta (显示 IL1B 蛋白) is produced by the epithelial cells, and that IL-1alpha is a more potent stimulator of prostaglandin and plasminogen (显示 PLG 蛋白) activator in bovine endometrial cells.
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
, interleukin-1 alpha
, preinterleukin 1 alpha
, interleukin 1-alpha
, Interleukin-1 alpha
, precursor interleukin-1alpha
, interleukin 1 alpha
, precursor interleukin 1 alpha