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IL12B 蛋白

(Interleukin 12 beta (IL12B))
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
Interleukin 12 beta (IL12B) (AA 23-328) protein (His tag) Interleukin 12 beta (IL12B) (AA 23-328) protein (His tag) Interleukin 12 beta (IL12B) (AA 23-328) protein (His tag) (ABIN1019696)

IL12B 宿主: 人 宿主: Tobacco (Nicotiana benthamiana) Recombinant > 97 % by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue. Imm, WB

Interleukin 12 beta (IL12B) (AA 23-328), (full length) protein (GST tag) Interleukin 12 beta (IL12B) (AA 23-328), (full length) protein (GST tag) Interleukin 12 beta (IL12B) (AA 23-328), (full length) protein (GST tag) (ABIN1047232)

IL12B 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant 90 % ELISA

Interleukin 12 beta (IL12B) (AA 23-328) protein (Fc Tag) Interleukin 12 beta (IL12B) (AA 23-328) protein (Fc Tag) Interleukin 12 beta (IL12B) (AA 23-328) protein (Fc Tag) (ABIN2181332)

IL12B 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.

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Find IL12B 蛋白 for a variety of species such as anti-Human IL12B, anti-Mouse IL12B, anti-Goat IL12B. The species listed below are among those available. Click on a link to go to the corresponding products.

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Popular IL12B 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN2181334
Quantity 50 μg
Datasheet Datasheet
Reactivity Sheep
Source Yeast
Validations
  • (2)
Cat. No. ABIN1476680
Quantity 500 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093148
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134079
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5569897
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307678
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect cells (Sf9)
Validations
  • (1)
Cat. No. ABIN2723603
Quantity 20 μg
Datasheet Datasheet
Reactivity Sheep
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709731
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2723602
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Human Cells
Validations
Cat. No. ABIN4371190
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
Cat. No. ABIN4371797
Quantity 50 μg
Datasheet Datasheet
Reactivity Goat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7084112
Quantity 50 μg
Datasheet Datasheet
Reactivity Zebrafish (Danio rerio)
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7084113
Quantity 50 μg
Datasheet Datasheet
Reactivity Guinea Pig
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7084114
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7084111
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our IL12B 蛋白

Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: "Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system." in: Nature immunology, Vol. 16, Issue 3, pp. 237-45, (2015) (PubMed).

Huang, Cancilla, Morahan: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." in: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).

Prussin, Metcalfe: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).

Ling, Gately, Gubler, Stern, Lin, Hollfelder, Su, Pan, Hakimi: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).

DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).

DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).

Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: "Cloning and expression of murine IL-12." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).

Wolf, Temple, Kobayashi, Young, Dicig, Lowe, Dzialo, Fitz, Ferenz, Hewick: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).

Gubler, Chua, Schoenhaut, Dwyer, McComas, Motyka, Nabavi, Wolitzky, Quinn, Familletti: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).

Aliases for IL12B 蛋白

interleukin 12B (IL12B) 蛋白
interleukin 12b (Il12b) 蛋白
interleukin 12B (Il12b) 蛋白
interleukin 12Ba (il12ba) 蛋白
CLMF 蛋白
CLMF2 蛋白
CLMF p40 蛋白
IL-12 蛋白
IL-12 p40 蛋白
IL-12.p40 蛋白
IL-12B 蛋白
Il-12b 蛋白
Il-12p40 蛋白
IL-12p40 蛋白
Il12 蛋白
il12b 蛋白
IL12B 蛋白
Il12p40 蛋白
IL12p40 蛋白
il12p40.b 蛋白
NKSF 蛋白
NKSF2 蛋白
p40 蛋白
zgc:152789 蛋白
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