IL12B 蛋白
(Interleukin 12 beta (IL12B))
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| IL12B Protein (AA 35-302) (His tag) | 小鼠 | 大肠杆菌（E. Coli） |
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| IL12B Protein (AA 21-315) (His tag) | 小鸡 | 大肠杆菌（E. Coli） |
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| IL12B Protein (AA 23-329) (His tag) | 马 | 大肠杆菌（E. Coli） |
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| IL12B Protein (AA 30-311) (His tag) | 大鼠 | 大肠杆菌（E. Coli） |
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| IL12B Protein (AA 23-324) (His tag,GST tag) | Pig | 大肠杆菌（E. Coli） |
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| IL12B Protein (AA 1-335) (His tag) | 小鼠 | HEK-293 Cells |
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| IL12B Protein (AA 1-335) (His tag) | 大鼠 | HEK-293 Cells |
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| IL12B Protein (AA 23-328) | 人 | HEK-293 Cells |
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| IL12B Protein (AA 23-327) | Cow | HEK-293F Cells |
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| IL12B Protein (AA 30-320) | 人 | 大肠杆菌（E. Coli） |
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| IL12B Protein (AA 23-327, full length) (His tag) | 绵羊 | 酵母菌 |
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| IL12B Protein (AA 23-328, full length) (GST tag) | 人 | 大肠杆菌（E. Coli） |
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| IL12B Protein (AA 23-328) (Fc Tag) | 人 | HEK-293 Cells |
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| IL12B Protein (AA 23-327) (His tag) | 绵羊 | 大肠杆菌（E. Coli） |
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| IL12B Protein (DYKDDDDK Tag) | 人 | Insect cells (Sf9) |
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| IL12B Protein (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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| IL12B Protein (AA 23-329) (His tag) | 马 | 酵母菌 |
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| IL12B Protein (AA 23-332) (His tag) | 豚鼠 | 酵母菌 |
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| IL12B Protein (AA 23-327) (His tag) | Golden Syrian Hamster | 酵母菌 |
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| IL12B Protein (AA 23-330) (His tag) | Llama | 酵母菌 |
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Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 小鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 小鸡
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 马
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- 大鼠
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
Protein
- WB (Western Blotting: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- Imm (Immunogen: 所列应用)
- PC (Positive Control: 所列应用)
- 宿主
- Pig
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 97 %
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 小鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
Protein
- Imm (Immunogen: 所列应用)
- 宿主
- 大鼠
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
Protein
- AcA (Activity Assay: 所列应用)
- CC (Cell Culture: 所列应用)
- 宿主
- Cow
- 宿主
- HEK-293F Cells
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
- 生物活性
- Active
Protein
- AcA (Activity Assay: 所列应用)
- CC (Cell Culture: 所列应用)
- 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- > 95 %
- 生物活性
- Active
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 所列应用)
- 宿主
- 绵羊
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 所列应用)
3 references - 宿主
- 人
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- 90 %
Protein
- SDS (SDS-PAGE: 有验证图片)
- ELISA (ELISA: 有验证图片)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- >95 % as determined by SDS-PAGE.
Protein
- SDS (SDS-PAGE: 有验证图片)
- 宿主
- 绵羊
- 宿主
- 大肠杆菌（E. Coli）
- 蛋白类型
- Recombinant
- 纯度
- Greater than 90 % as determined by SDS-PAGE.
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- Insect cells (Sf9)
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- 马
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- 豚鼠
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- Golden Syrian Hamster
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Protein
- ELISA (ELISA: 所列应用)
- 宿主
- Llama
- 宿主
- 酵母菌
- 蛋白类型
- Recombinant
- 纯度
- > 90 %
Latest Publications for our IL12B 蛋白
: "Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system." in: Nature immunology, Vol. 16, Issue 3, pp. 237-45, (2015) (PubMed).
: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." in: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).
: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).
: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).
: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).
: "Cloning and expression of murine IL-12." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).
: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).
: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).
: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." in: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).
: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).
: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).
: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).
: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).
: "Cloning and expression of murine IL-12." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).
: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).
: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).
Aliases for IL12B 蛋白
interleukin 12B (IL12B) 蛋白interleukin 12b (Il12b) 蛋白
interleukin 12B (Il12b) 蛋白
interleukin 12Ba (il12ba) 蛋白
CLMF 蛋白
CLMF2 蛋白
CLMF p40 蛋白
IL-12 蛋白
IL-12 p40 蛋白
IL-12.p40 蛋白
IL-12B 蛋白
Il-12b 蛋白
Il-12p40 蛋白
IL-12p40 蛋白
Il12 蛋白
il12b 蛋白
IL12B 蛋白
Il12p40 蛋白
IL12p40 蛋白
il12p40.b 蛋白
NKSF 蛋白
NKSF2 蛋白
p40 蛋白
zgc:152789 蛋白
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